Human Paraoxonase 1: From Bloodstream Enzyme to Disease Fighter & Therapeutic Intervention.

IF 1.9 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current protein & peptide science Pub Date : 2024-12-24 DOI:10.2174/0113892037335325241011162207

Prakash Y Khandave, Khushi Goyal, Prakashkumar Dobariya, Abhay H Pande

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引用次数: 0

Abstract

Human paraoxonase 1 (hPON1) is a Ca2+-dependent metalloenzyme with multifunctional properties. Due to its diverse roles as arylesterase, phosphotriesterase, and lactonase, it plays a significant role in disease conditions. Researchers across the globe have demonstrated different properties of PON1, like anti-oxidant, anti-inflammatory, anti-atherogenic, anti-diabetic, and OPneutralization. Due to its pleotropic role in disease conditions like atherosclerosis, diabetes, cardiovascular diseases, neurodegenerative disorders, and OP-poisoning, it can be considered as a potential candidate for the development of therapeutic interventions. Attempts are being made in this direction to identify the exact role of PON1 in these disease conditions. Different approaches like directed evolution, genetic as well as chemical fusion, liposomal delivery of PON1, etc., are being developed and evaluated for their therapeutic effects in different pathological pathways. In this review, we outline the exact role and involvement of different properties of PON1 in the pathophysiology of different diseases and how it can be utilized and developed as a therapeutic intervention in PON1-associated disease conditions.

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人对氧磷酶1：从血液酶到疾病斗士及治疗干预。

人对氧磷酶1 （hPON1）是一种Ca2+依赖性金属酶，具有多种功能。由于其作为芳基酯酶、磷酸三酯酶和内酯酶的不同作用，它在疾病状况中起着重要作用。世界各地的研究人员已经证明了PON1的不同特性，如抗氧化、抗炎、抗动脉粥样硬化、抗糖尿病和OPneutralization。由于其在动脉粥样硬化、糖尿病、心血管疾病、神经退行性疾病和op中毒等疾病中的多效性作用，它可以被认为是开发治疗干预措施的潜在候选者。人们正朝着这个方向努力，以确定PON1在这些疾病条件中的确切作用。不同的方法，如定向进化、遗传和化学融合、PON1脂质体递送等，正在开发和评估其在不同病理途径中的治疗效果。在这篇综述中，我们概述了PON1的不同特性在不同疾病的病理生理中的确切作用和参与，以及它如何被利用和发展为PON1相关疾病的治疗干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current protein & peptide science 生物-生化与分子生物学

CiteScore

5.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.