Positive correlation between n- 6 : n- 3 PUFA ratio intake with serum oxHDL/HDL-c ratio in patients with coronary artery disease.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Coronary artery disease Pub Date : 2025-05-01 Epub Date: 2024-10-16 DOI:10.1097/MCA.0000000000001437

Sissi Godinez-Mora, Wendy Campos-Perez, Mariana Perez-Robles, Cesar Robles-Jimarez, Alejandra Muñoz-Hernandez, Joel Torres-Vanegas, Erika Martinez-Lopez

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引用次数: 0

Abstract

Background: Coronary artery disease (CAD) is one of the most prevalent cardiovascular diseases where serum lipoprotein oxidation plays a significant role. Polyunsaturated fatty acids (PUFA) n -6 : n -3 unbalance ratio consumption, affects lipoprotein oxidation, and inflammation processes. This study aimed to analyze the relationship between n -6 : n -3 PUFA ratio intake with oxidized lipoproteins in individuals with CAD.

Methods: A cross-sectional study was performed including 105 subjects (51 diagnosed with CAD and 54 non-CAD) from western Mexico. Dietary information was collected using a habitual day food record. Serum oxidized low-density lipoprotein (oxLDL) and oxidized high-density lipoprotein (oxHDL) concentrations were quantified by enzyme linked immunosorbent assay.

Results: CAD subjects had higher oxHDL/HDL cholesterol (HDL-c) ratio [0.102 (0.092-0.112) vs. 0.080 (0.070-0.090), P = 0.004] and oxLDL/LDL cholesterol (LDL-c) ratio [129.2 (108-150.4) vs. 59.7 (39.3-80), P < 0.001] compared to non-CAD subjects. Risk factors associated with CAD were a high n -6 : n -3 PUFA ratio (odds ratio, OR = 2.3, P = 0.046), hypoalphalipoproteinemia in men (OR = 3.2, P = 0.014), moderate/high tobacco index (OR = 6.33, P = 0.003), elevated waist circumference in women (OR = 7, P = 0.004), hypertension (OR = 21.14, P < 0.001), and type 2 diabetes (OR: 25, P < 0.001). The oxHDL/HDL-c ratio was positively associated with the n -6 : n -3 PUFA ratio [ r2 = 28.3, B = 0.002 (0.001-0.003), P < 0.001] in CAD patients.

Conclusions: This study showed that a higher n -6 : n -3 PUFA ratio intake correlates with higher serum oxHDL/HDL-c in CAD patients.

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冠心病患者n-6: n-3 PUFA比值摄入与血清oxHDL/HDL-c比值正相关

背景：冠状动脉疾病（CAD）是最常见的心血管疾病之一，血清脂蛋白氧化在其中起着重要作用。多不饱和脂肪酸（PUFA） n-6: n-3比例不平衡消耗，影响脂蛋白氧化和炎症过程。本研究旨在分析冠心病患者n-6: n-3 PUFA比值摄入与氧化脂蛋白之间的关系。方法：横断面研究包括来自墨西哥西部的105名受试者（51名诊断为CAD， 54名非CAD）。通过日常饮食记录收集饮食信息。采用酶联免疫吸附法测定血清氧化低密度脂蛋白（oxLDL）和氧化高密度脂蛋白（oxHDL）浓度。结果：冠心病患者oxHDL/HDL-c比值较高[0.102 (0.092-0.112)vs. 0.080 (0.070-0.090), P = 0.004]， oxLDL/LDL -c比值较高[129.2 (108-150.4)vs. 59.7 (39.3-80)， P结论：本研究表明，较高的n-6: n-3 PUFA比值摄入与冠心病患者血清oxHDL/HDL-c升高相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Coronary artery disease 医学-外周血管病

CiteScore

2.50

自引率

0.00%

发文量

190

审稿时长

6-12 weeks

期刊介绍： Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management. Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.