Cell-type-specific auditory responses in the striatum are shaped by feedforward inhibition.

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Cell reports Pub Date : 2024-12-24 DOI:10.1016/j.celrep.2024.115090

Mélanie Druart, Megha Kori, Corryn Chaimowitz, Catherine Fan, Tanya Sippy

引用次数: 0

Abstract

The posterior "tail" region of the striatum receives dense innervation from sensory brain regions and is important for behaviors that require sensorimotor integration. The output neurons of the striatum, D1 and D2 striatal projection neurons (SPNs), which make up the direct and indirect pathways, are thought to play distinct functional roles, although it remains unclear if these neurons show cell-type-specific differences in their response to sensory stimuli. Here, we examine the strength of synaptic inputs onto D1 and D2 SPNs following the stimulation of upstream auditory pathways. We report that auditory-evoked depolarizations onto D1 SPN responses are stronger and faster. This is due to differences in feedforward inhibition, with fast-spiking interneurons forming stronger synapses onto D2 SPNs. Our results support a model in which differences in feedforward inhibition enable the preferential recruitment of D1 SPNs by auditory stimuli, positioning the direct pathway to initiate sound-driven actions.

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纹状体中细胞类型特异性听觉反应是由前馈抑制形成的。

纹状体的后“尾”区接受来自感觉脑区的密集神经支配，对需要感觉运动整合的行为很重要。纹状体的输出神经元D1和D2纹状体投射神经元（spn）构成了直接和间接通路，被认为发挥着不同的功能作用，尽管尚不清楚这些神经元在对感觉刺激的反应中是否表现出细胞类型特异性差异。在这里，我们研究了上游听觉通路刺激后突触输入到D1和D2 spn的强度。我们报告了听觉诱发的D1 SPN去极化反应更强、更快。这是由于前馈抑制的差异，快速尖峰的中间神经元在D2 spn上形成更强的突触。我们的研究结果支持了一个模型，在这个模型中，前馈抑制的差异使听觉刺激优先募集D1 spn，定位了启动声音驱动动作的直接途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell reports CELL BIOLOGY-

CiteScore

13.80

自引率

1.10%

发文量

1305

审稿时长

77 days

期刊介绍： Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.