Adiposity and inflammation markers explain mostly part of the plasma zonulin variation in Brazilian adults with overweight/obesity: A cross-sectional analysis from Brazilian nuts study

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition Pub Date : 2025-02-01 DOI:10.1016/j.clnu.2024.12.017

Madalena Geralda Cupertino Ribeiro , Ana Claudia Pelissari Kravchychyn , Josefina Bressan , Helen Hermana Miranda Hermsdorff

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引用次数: 0

Abstract

Objective

This study evaluated intestinal permeability according to plasma zonulin and its association with adiposity, inflammation, cardiometabolic risk, liver function, and intestinal health markers in adults with overweight/obesity.

Methodology

This study is a cross-sectional analysis using baseline data from the Brazilian Nut Study, which involved 123 participants (93 women, age 33.2 ± 8.58 years, BMI 33.9 ± 4.30kg/m2). Subjects were divided into quartiles according to plasma zonulin, assessed by Elisa. Cytokines were assessed by flow cytometry; anthropometric measurements were collected by standard procedure and body composition was assessed by DXA. SCFA analysis was performed by high-performance liquid chromatography, and fecal pH, by a pH meter. Linear regression models were performed (α<5 %).

Results

Participants included in the last quartile of plasma zonulin had higher values of body fat (%), pro-inflammatory cytokines (CRP, IL-1). According to the multivariate regression model, each one-unit increased in body fat, CRP, IL-12p70, IL-6 and IL-8 resulted correspondingly in an increment of 0.42, 0.14, 0.192, 0.250 and 0.312 ng/ml in plasma zonulin, respectively. Conversely, a one-unit decreased in IL-10 led to an increase of 0.40 ng/ml in plasma zonulin.

Conclusion

Intestinal permeability assessed by plasma zonulin is associated with adiposity, subclinical inflammation and reduced serum HDL levels adults with overweight/obesity, while adiposity and inflammation markers are independent factors for plasma zonulin variation.

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肥胖和炎症标志物解释了巴西超重/肥胖成年人血浆带蛋白变化的大部分原因：巴西坚果研究的横断面分析。

目的：本研究评估了超重/肥胖成人血浆zonulin的肠通透性及其与肥胖、炎症、心脏代谢风险、肝功能和肠道健康指标的关系。方法：本研究采用巴西坚果研究基线数据的横断面分析，涉及123名参与者（93名女性，年龄33.2±8.58岁，BMI 33.9±4.30kg/m2）。根据血浆zonulin水平将受试者分为四分位数，采用Elisa法进行评估。流式细胞术检测细胞因子；采用标准程序采集人体测量数据，采用DXA评估体成分。SCFA分析采用高效液相色谱法，粪便pH测定采用pH计。采用线性回归模型(α结果：血浆zonulin最后四分位数的参与者体脂（%）、促炎细胞因子（CRP、IL-1）值较高。根据多元回归模型，体脂、CRP、IL-12p70、IL-6、IL-8每增加1个单位，血浆带蛋白分别增加0.42、0.14、0.192、0.250、0.312 ng/ml。相反，IL-10降低1个单位导致血浆带蛋白升高0.40 ng/ml。结论：血浆zonulin评估肠道通透性与肥胖、亚临床炎症和血清HDL水平降低有关，而肥胖和炎症标志物是血浆zonulin变化的独立因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition 医学-营养学

CiteScore

14.10

自引率

6.30%

发文量

356

审稿时长

28 days

期刊介绍： Clinical Nutrition, the official journal of ESPEN, The European Society for Clinical Nutrition and Metabolism, is an international journal providing essential scientific information on nutritional and metabolic care and the relationship between nutrition and disease both in the setting of basic science and clinical practice. Published bi-monthly, each issue combines original articles and reviews providing an invaluable reference for any specialist concerned with these fields.