{"title":"Pyridazine and pyridazinone compounds in crops protection: a review.","authors":"Xining Ma, Ping Sun, Jiaxin Wang, Xinyu Huang, Jian Wu","doi":"10.1007/s11030-024-11083-5","DOIUrl":null,"url":null,"abstract":"<p><p>Pyridazine and pyridazinone belong to the same group of six-membered heterocyclic compounds, and both structurally feature two adjacent nitrogen atoms. Pyridazine and pyridazinone derivatives are frequently used as core structures in the development of new green agrochemicals due to their high activity and environmental friendliness, attracting significant attention from researchers in recent years. Over the past 20 years, significant developments have occurred in the field of pyridazine and pyridazinone derivatives, which exhibit insecticidal, fungicidal, herbicidal, antiviral, and plant growth regulating activities. Hence, summarizing the process of creating novel molecules with pyridazine and pyridazinone structures through design concepts, understanding structure-activity relationships, and mechanisms of action is an important undertaking. This review aims to provide a comprehensive overview of these advancements, shedding light on the discovery and mechanism of action of novel pesticides in the pyridazine and pyridazinone categories.</p>","PeriodicalId":708,"journal":{"name":"Molecular Diversity","volume":" ","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Diversity","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s11030-024-11083-5","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Pyridazine and pyridazinone belong to the same group of six-membered heterocyclic compounds, and both structurally feature two adjacent nitrogen atoms. Pyridazine and pyridazinone derivatives are frequently used as core structures in the development of new green agrochemicals due to their high activity and environmental friendliness, attracting significant attention from researchers in recent years. Over the past 20 years, significant developments have occurred in the field of pyridazine and pyridazinone derivatives, which exhibit insecticidal, fungicidal, herbicidal, antiviral, and plant growth regulating activities. Hence, summarizing the process of creating novel molecules with pyridazine and pyridazinone structures through design concepts, understanding structure-activity relationships, and mechanisms of action is an important undertaking. This review aims to provide a comprehensive overview of these advancements, shedding light on the discovery and mechanism of action of novel pesticides in the pyridazine and pyridazinone categories.
期刊介绍：
Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including:
combinatorial chemistry and parallel synthesis;
small molecule libraries;
microwave synthesis;
flow synthesis;
fluorous synthesis;
diversity oriented synthesis (DOS);
nanoreactors;
click chemistry;
multiplex technologies;
fragment- and ligand-based design;
structure/function/SAR;
computational chemistry and molecular design;
chemoinformatics;
screening techniques and screening interfaces;
analytical and purification methods;
robotics, automation and miniaturization;
targeted libraries;
display libraries;
peptides and peptoids;
proteins;
oligonucleotides;
carbohydrates;
natural diversity;
new methods of library formulation and deconvolution;
directed evolution, origin of life and recombination;
search techniques, landscapes, random chemistry and more;
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