Benjamin Alexander, Eli Contorno, Herra Javed, Nicholas Callais, Taufiek K Rajab
{"title":"Domino partial heart transplantation.","authors":"Benjamin Alexander, Eli Contorno, Herra Javed, Nicholas Callais, Taufiek K Rajab","doi":"10.1016/j.ajt.2024.12.013","DOIUrl":null,"url":null,"abstract":"<p><p>Heart valve replacement in pediatric cardiothoracic surgery poses problems because conventional heart valve implants do not have the ability to grow. This mandates serial reoperations for implant exchanges until an adult-size implant can fit. Partial heart transplantation eliminates these reoperations because the transplanted valves grow. However, partial heart transplantation competes with heart transplantation for a limited supply of donor hearts. This is a critical barrier to the progress of the field. Domino partial heart transplantation is a new surgical technique that overcomes this barrier by capitalizing cardiectomy hearts from heart transplant recipients for partial heart transplantation. This surgical technique has the potential to transform pediatric heart valve replacement by greatly expanding the cardiac donor pool, increasing the time available for matching donors with recipients and simplifying the logistics of donation. As a result, the number of domino partial heart transplants is expected to exceed the number of partial heart transplants from deceased donors.</p>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9000,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Transplantation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ajt.2024.12.013","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
Heart valve replacement in pediatric cardiothoracic surgery poses problems because conventional heart valve implants do not have the ability to grow. This mandates serial reoperations for implant exchanges until an adult-size implant can fit. Partial heart transplantation eliminates these reoperations because the transplanted valves grow. However, partial heart transplantation competes with heart transplantation for a limited supply of donor hearts. This is a critical barrier to the progress of the field. Domino partial heart transplantation is a new surgical technique that overcomes this barrier by capitalizing cardiectomy hearts from heart transplant recipients for partial heart transplantation. This surgical technique has the potential to transform pediatric heart valve replacement by greatly expanding the cardiac donor pool, increasing the time available for matching donors with recipients and simplifying the logistics of donation. As a result, the number of domino partial heart transplants is expected to exceed the number of partial heart transplants from deceased donors.
期刊介绍：
The American Journal of Transplantation is a leading journal in the field of transplantation. It serves as a forum for debate and reassessment, an agent of change, and a major platform for promoting understanding, improving results, and advancing science. Published monthly, it provides an essential resource for researchers and clinicians worldwide.
The journal publishes original articles, case reports, invited reviews, letters to the editor, critical reviews, news features, consensus documents, and guidelines over 12 issues a year. It covers all major subject areas in transplantation, including thoracic (heart, lung), abdominal (kidney, liver, pancreas, islets), tissue and stem cell transplantation, organ and tissue donation and preservation, tissue injury, repair, inflammation, and aging, histocompatibility, drugs and pharmacology, graft survival, and prevention of graft dysfunction and failure. It also explores ethical and social issues in the field.
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