Silent circulation of plasmid-borne tet(X6) and blaOXA-58 genes in a community-acquired Acinetobacter baumannii strain

IF 15.8 1区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Resistance Updates Pub Date : 2024-12-25 DOI:10.1016/j.drup.2024.101194

Huiqiong Jia , Qingchao Tong , Le Wang , Yuye Wu , Xinyang Li , Shuangshuang Li , Yingying Kong , Yingying Zhang , João Pedro Rueda Furlan , Nwai Oo Khine , Patrick Butaye , Jun Zhang , Qing Yang , Zhi Ruan

引用次数: 0

Abstract

To characterize the genomic features of a community-acquired Acinetobacter baumannii strain, co-carrying tet(X6) and bla_OXA-58 genes, but was susceptible to tigecycline and carbapenems. The tet(X6) and bla_OXA-58 genes were found on a 149,518 bp non-conjugative plasmid. The bla_OXA-58 gene was silent, due to the presence of an intact ISAba3-like element upstream, which rendered the strain susceptible to carbapenems.

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一株社区获得性鲍曼不动杆菌质粒携带的tet（X6）和blaOXA-58基因的沉默循环

研究一株社区获得性鲍曼不动杆菌的基因组特征，该菌株共携带tet（X6）和blaOXA-58基因，但对替加环素和碳青霉烯类药物敏感。在149,518 bp的非共轭质粒上发现了tet（X6）和blaOXA-58基因。blaOXA-58基因是沉默的，由于上游存在一个完整的类似于isaba3的元件，这使得该菌株对碳青霉烯类敏感。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Resistance Updates 医学-药学

CiteScore

26.20

自引率

11.90%

发文量

审稿时长

29 days

期刊介绍： Drug Resistance Updates serves as a platform for publishing original research, commentary, and expert reviews on significant advancements in drug resistance related to infectious diseases and cancer. It encompasses diverse disciplines such as molecular biology, biochemistry, cell biology, pharmacology, microbiology, preclinical therapeutics, oncology, and clinical medicine. The journal addresses both basic research and clinical aspects of drug resistance, providing insights into novel drugs and strategies to overcome resistance. Original research articles are welcomed, and review articles are authored by leaders in the field by invitation. Articles are written by leaders in the field, in response to an invitation from the Editors, and are peer-reviewed prior to publication. Articles are clear, readable, and up-to-date, suitable for a multidisciplinary readership and include schematic diagrams and other illustrations conveying the major points of the article. The goal is to highlight recent areas of growth and put them in perspective. *Expert reviews in clinical and basic drug resistance research in oncology and infectious disease *Describes emerging technologies and therapies, particularly those that overcome drug resistance *Emphasises common themes in microbial and cancer research