Late-life social activity and subsequent risk of dementia and mild cognitive impairment

IF 13 1区 医学 Q1 CLINICAL NEUROLOGY
Yi Chen, Francine Grodstein, Ana W. Capuano, Tianhao Wang, David A. Bennett, Bryan D. James
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Abstract

INTRODUCTION

Social activity is associated with better cognitive health in old age. To better translate epidemiological research for public health communication, we estimated relations of levels of social activity to average age at dementia onset.

METHODS

In the Rush Memory and Aging Project (MAP), we followed 1923 dementia-free older adults and conducted annual clinical evaluations of dementia/mild cognitive impairment (MCI).

RESULTS

During a mean follow-up of 6.7 (SD = 4.7) years, 545 participants developed dementia, and 695 developed MCI. Using Accelerated Failure Time models adjusted for age, sex, education, race/ethnicity, and marital status, we found predicted mean age of dementia onset for the least socially active was 87.7 years, approximately 5 years earlier than the most socially active (mean age = 92.2, p < .01); we found a similar 5-year difference in age at MCI onset by social activity.

DISCUSSION

Our findings highlight the value of social activity as a possible community-level intervention for reducing dementia.

Highlights

  • Accelerated failure time models estimated age at dementia onset by social activity level to aid interpretation.
  • Higher social activity was associated with a 5-year older age at dementia onset.
  • Economic research shows a 5-year delay translates to US$500,000 of healthcare savings per capita.
  • Our findings help understand the public health significance of social activity.

Abstract Image

晚年社交活动与痴呆和轻度认知障碍的风险
社会活动与老年人更好的认知健康有关。为了更好地将流行病学研究转化为公共卫生传播,我们估计了社会活动水平与痴呆症发病时的平均年龄之间的关系。方法在Rush记忆与衰老项目(MAP)中,我们随访了1923名无痴呆的老年人,并对痴呆/轻度认知障碍(MCI)进行了年度临床评估。结果在平均6.7年(SD = 4.7)的随访期间,545名参与者发展为痴呆,695名参与者发展为轻度认知障碍。使用年龄、性别、教育程度、种族/民族和婚姻状况调整后的加速失效时间模型,我们发现社交活动最少的人预测痴呆发病的平均年龄为87.7岁,比社交活动最多的人早约5岁(平均年龄= 92.2岁,p <;. 01);我们发现社交活动在轻度认知障碍发病年龄上存在类似的5岁差异。讨论:我们的研究结果强调了社会活动作为减少痴呆的可能的社区水平干预的价值。强调加速失效时间模型通过社会活动水平估计痴呆发病年龄,以帮助解释。较高的社会活动与老年痴呆发病年龄大于5岁相关。经济研究表明,延迟5年可为人均医疗保健节省50万美元。我们的发现有助于理解社会活动对公共健康的影响。
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来源期刊
Alzheimer's & Dementia
Alzheimer's & Dementia 医学-临床神经学
CiteScore
14.50
自引率
5.00%
发文量
299
审稿时长
3 months
期刊介绍: Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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