Design and Characterization of Polyvinyl Alcohol/Kappa-Carrageenan Pickering Emulsion Biocomposite Films for Potential Wound Care Applications

IF 3.9 3区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of biomedical materials research. Part A Pub Date : 2024-12-25 DOI:10.1002/jbm.a.37850

Ayşenur Yeşilyurt, Gopiraman Mayakrishnan, Uğur Parın, Ick Soo Kim, Fatma Nur Parın, Azeem Ullah

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Abstract

This study aimed to develop polyvinyl alcohol (PVA) and kappa-carrageenan (κCA) biocomposite films using a Pickering emulsion technique for wound care applications. Juniper essential oil and modified sepiolite were incorporated to enhance functionality, with films prepared via solvent casting and characterized for structural, thermal, and mechanical properties. The PCOS-2 film exhibited the highest mechanical performance, with Young's modulus of 6.25 ± 1.3 MPa, tensile strength of 5.65 ± 1.7 MPa, and elongation at break of 608.96% ± 72.8%. Antibacterial assays showed inhibition zones of 9 and 10 mm against Staphylococcus aureus and Escherichia coli, respectively, for the PCOS-2 film, while antioxidant activity reached 63% DPPH radical scavenging after 12 h. Additionally, porosity and hydrophilicity were enhanced, as indicated by contact angles of 55° for the control film and 71.2° for PCOS-2. These results underscore the potential of PVA/κCA biocomposite films as sustainable and bioactive wound dressings, combining mechanical resilience, bioactivity, and environmental compatibility, with future efforts focused on optimizing antibacterial efficacy against gram-negative bacteria and clinical validation.

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聚乙烯醇/ kappa -卡拉胶酸洗乳生物复合膜的设计与表征

本研究旨在利用皮克林乳剂技术制备聚乙烯醇(PVA) -卡拉胶（κCA）生物复合膜，用于伤口护理。加入杜松精油和改性海泡石来增强功能，通过溶剂铸造制备薄膜，并表征结构，热学和机械性能。PCOS-2薄膜的力学性能最高，杨氏模量为6.25±1.3 MPa，抗拉强度为5.65±1.7 MPa，断裂伸长率为608.96%±72.8%。抑菌实验表明，PCOS-2膜对金黄色葡萄球菌和大肠杆菌的抑制区分别为9 mm和10 mm， 12 h后DPPH自由基清除率达到63%。此外，对照膜的接触角为55°，PCOS-2的接触角为71.2°，孔隙度和亲水性都得到了增强。这些结果强调了PVA/κCA生物复合膜作为可持续和生物活性伤口敷料的潜力，结合了机械弹性、生物活性和环境相容性，未来的工作重点是优化对革兰氏阴性菌的抗菌效果和临床验证。

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来源期刊

Journal of biomedical materials research. Part A 工程技术-材料科学：生物材料

CiteScore

10.40

自引率

2.00%

发文量

135

审稿时长

3.6 months

期刊介绍： The Journal of Biomedical Materials Research Part A is an international, interdisciplinary, English-language publication of original contributions concerning studies of the preparation, performance, and evaluation of biomaterials; the chemical, physical, toxicological, and mechanical behavior of materials in physiological environments; and the response of blood and tissues to biomaterials. The Journal publishes peer-reviewed articles on all relevant biomaterial topics including the science and technology of alloys,polymers, ceramics, and reprocessed animal and human tissues in surgery,dentistry, artificial organs, and other medical devices. The Journal also publishes articles in interdisciplinary areas such as tissue engineering and controlled release technology where biomaterials play a significant role in the performance of the medical device. The Journal of Biomedical Materials Research is the official journal of the Society for Biomaterials (USA), the Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Articles are welcomed from all scientists. Membership in the Society for Biomaterials is not a prerequisite for submission.