Lipoprotein(a) and the risk of type I cardiorenal syndrome in patients with coronary artery disease: A retrospective clinical study

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

IJC Heart and Vasculature Pub Date : 2025-02-01 DOI:10.1016/j.ijcha.2024.101568

Zhenhua Jiang, Hailiang Ma, Jianqiang Meng, Dewen Zhu, Yuanben Lu

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引用次数: 0

Abstract

Objective

The present study aimed to investigate the correlation between lipoprotein(a) (Lp-a) and coronary artery disease (CAD) complicated by type I cardiorenal syndrome (CRS).

Methods

We conducted a retrospective analysis of patients diagnosed with CAD admitted to the Department of Cardiovascular Medicine at Shaoxing Central Hospital from January 2021 to December 2022, with chief complaints of “chest distress and dyspnea.” Patient demographic data, biochemical indicators (including blood lipid levels and serum creatinine), cardiac function markers (such as pro-brain natriuretic peptide, pro-BNP), echocardiography, and coronary angiography results were collected. Patients were categorized into two groups based on estimated glomerular filtration rate (e-GFR): the CRS group (e-GFR < 60 mL/min/1.73 m²) and the simple heart failure group (SHF group, e-GFR ≥ 60 mL/min/1.73 m²). A comparative analysis of baseline characteristics, lipid profiles, ejection fraction (LVEF), left atrial size (LA), end-diastolic interventricular septal thickness (IVSd), left ventricular end-diastolic dimension (LVEDD), and left ventricular end-systolic dimension (LVESD) between the two groups was performed. Multivariable logistic regression analysis was applied to assess the association between serum lipoprotein(a) (Lp-a) levels and the occurrence of CRS.

Results

A total of 269 patients were included, comprising 149 males and 120 females with an average age of 76.0 ± 11.4 years. Significant differences were observed between the CRS and SHF groups in terms of age, history of hypertension, diabetes, myocardial infarction, serum triglycerides, Lp-a, and creatinine (all P < 0.05). Spearman’s correlation analysis revealed an inverse relationship between Lp-a and e-GFR (r = -0.588, P < 0.05). Multivariable logistic regression analysis indicated that Lp-a (OR = 1.980, 95 % CI: 1.269–2.992, P = 0.027) and age (OR = 1.584, 95 % CI: 0.955–1.913, P = 0.006) were positively associated with the development of CRS.

Conclusion

Serum Lp-a levels are positively correlated with the occurrence of CRS, potentially serving as an independent risk factor for CRS.

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脂蛋白(a)与冠心病患者I型心肾综合征的风险：一项回顾性临床研究

目的：探讨脂蛋白(a) （Lp-a）与冠心病（CAD）合并I型心肾综合征（CRS）的相关性。方法：我们对2021年1月至2022年12月在绍兴市中心医院心血管内科确诊为CAD的患者进行回顾性分析，这些患者的主诉为“胸闷和呼吸困难”。收集患者人口学资料、生化指标（包括血脂水平、血清肌酐）、心功能指标（如脑利钠肽、bnp前体）、超声心动图、冠状动脉造影结果。根据估计的肾小球滤过率（e-GFR）将患者分为两组：CRS组（e-GFR < 60 mL/min/1.73 m2）和单纯性心力衰竭组（SHF组，e-GFR≥60 mL/min/1.73 m2）。比较分析两组患者的基线特征、血脂、射血分数（LVEF）、左房尺寸（LA）、舒张末期室间隔厚度（IVSd）、左室舒张末期尺寸（LVEDD）和左室收缩末期尺寸（LVESD）。采用多变量logistic回归分析评估血清脂蛋白(a) （Lp-a）水平与CRS发生的关系。结果：共纳入269例患者，其中男性149例，女性120例，平均年龄76.0±11.4岁。CRS组与SHF组在年龄、高血压史、糖尿病史、心肌梗死史、血清甘油三酯、Lp-a、肌酐等指标差异均有统计学意义（P < 0.05）。Spearman相关分析显示，Lp-a与e-GFR呈负相关（r = -0.588, P < 0.05）。多变量logistic回归分析显示，Lp-a （OR = 1.980, 95% CI: 1.269 ~ 2.992, P = 0.027）和年龄（OR = 1.584, 95% CI: 0.955 ~ 1.913, P = 0.006）与CRS的发生呈正相关。结论：血清Lp-a水平与CRS发生呈正相关，可能是CRS发生的独立危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IJC Heart and Vasculature Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.90

自引率

10.30%

发文量

216

审稿时长

56 days

期刊介绍： IJC Heart & Vasculature is an online-only, open-access journal dedicated to publishing original articles and reviews (also Editorials and Letters to the Editor) which report on structural and functional cardiovascular pathology, with an emphasis on imaging and disease pathophysiology. Articles must be authentic, educational, clinically relevant, and original in their content and scientific approach. IJC Heart & Vasculature requires the highest standards of scientific integrity in order to promote reliable, reproducible and verifiable research findings. All authors are advised to consult the Principles of Ethical Publishing in the International Journal of Cardiology before submitting a manuscript. Submission of a manuscript to this journal gives the publisher the right to publish that paper if it is accepted. Manuscripts may be edited to improve clarity and expression.