Evaluating hemodynamic response to treatment in patients with peripheral arterial disease using dynamic vascular optical spectroscopy.

IF 3 3区 医学 Q2 BIOCHEMICAL RESEARCH METHODS
Journal of Biomedical Optics Pub Date : 2024-12-01 Epub Date: 2024-12-24 DOI:10.1117/1.JBO.29.12.127001
Nisha Maheshwari, Alessandro Marone, Stephen H K Kim, Danielle R Bajakian, Andreas H Hielscher
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引用次数: 0

Abstract

Significance: Tracking changes in the vasculature of patients with peripheral arterial disease (PAD) may identify the need for follow-up treatment within only weeks after an initial intervention, enabling timely support and improving patient outcomes.

Aim: We aim to evaluate dynamic vascular optical spectroscopy's (DVOS's) ability to accurately monitor the hemodynamics of affected arteries in patients with PAD after a surgical intervention and predict long-term clinical outcomes.

Approach: A DVOS system non-invasively monitored the blood flow through 256 lower extremity arteries in 80 PAD patients immediately before, immediately after, and 3 to 4 weeks after they underwent a surgical intervention.

Results: Hemodynamic changes measured by DVOS after a revascularization procedure (RP) classified patient long-term ( 6.2 ± 4.4 months) outcomes with high accuracy [81.6% for patients with ulcers ( n = 31 ); 81.1% for patients without ulcers ( n = 54 )] by 3 to 4 weeks after the RP, outperforming available ankle-brachial index and ultrasound measurements. In addition, DVOS parameters distinguished between patients who underwent only a catheter angiography (CA) and patients who underwent both a CA and RP ( P < 0.05 ).

Conclusions: The DVOS system was able to classify patient long-term clinical outcomes with high accuracy within one month after an RP and distinguish among different interventions. DVOS may be a promising alternative or adjunct to existing monitoring approaches.

应用动态血管光谱学评价外周动脉疾病患者治疗后的血流动力学反应。
意义:跟踪外周动脉疾病(PAD)患者的血管变化,可以在初始干预后仅几周内确定是否需要随访治疗,从而及时支持并改善患者预后。目的:我们旨在评估动态血管光谱学(DVOS)在PAD患者手术干预后准确监测受影响动脉血流动力学的能力,并预测长期临床结果。方法:采用DVOS系统无创监测80例PAD患者在手术前、手术后和手术后3 - 4周内256条下肢动脉的血流。结果:血管重建术(RP)后DVOS测量的血流动力学变化对患者长期(6.2±4.4个月)结果的分类准确率很高[溃疡患者(n = 31)为81.6%;在RP术后3 - 4周内,无溃疡的患者占81.1% (n = 54),优于现有的踝臂指数和超声测量。此外,仅行导管血管造影(CA)的患者与同时行导管血管造影和RP的患者的dvs参数差异有统计学意义(P < 0.05)。结论:DVOS系统能够在RP术后1个月内对患者的长期临床结果进行高精度分类,并区分不同的干预措施。dvs可能是现有监测方法的一种有希望的替代方法或辅助方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.40
自引率
5.70%
发文量
263
审稿时长
2 months
期刊介绍: The Journal of Biomedical Optics publishes peer-reviewed papers on the use of modern optical technology for improved health care and biomedical research.
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