Determine Complete Blood Count Reference Values Among Healthy Adult Populations.

IF 2.1 Q3 HEMATOLOGY

Journal of Blood Medicine Pub Date : 2024-12-19 eCollection Date: 2024-01-01 DOI:10.2147/JBM.S488050

Abdul Baset Abbas, Abeer Aldomaini, Amah Alrahman Al-Qadri, Zahra'a Algorbani, Sara Aljamali, Safa Alsiri, Khadeeja Alghorbani, Saba Abo Osba'a

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引用次数: 0

Abstract

Background: Complete blood counts (CBC) are commonly used in diagnostic medicine to evaluate normal and abnormal hematological status. Furthermore, reference values (RVs) of CBC supplied by researchers are the most reliable means of the judgment-making stage and can aid interpretation and accurate diagnosis of diseases. Reference values vary between peoples because of differences in lifestyle, dietary habits, ethnicity and environment. Moreover, the Clinical and International Standards Institute (CISI) advises determining the RVs for each area. There are no RVs for CBC in Yemen. Therefore, this study aimed to determine the common RVs of CBC for healthy adults in Ibb City in the middle of Yemen.

Methods: A cross-sectional study was conducted from April 1, to November 30, 2023. Of the 623 adults who participated in this study, 433 (aged 18-80 years) were included in the final analysis after applying exclusion criteria. The mean, median, and 95^th percentile RVs (2.5^th-97.5^th percentiles) were calculated for gender, age, and residence by the GraphPad Prism 8.0.1.

Results: The RVs of hemoglobin (Hb) 11.16-17.54g/dl, red blood cells (RBC) 3.890-6.340×10¹²/l, hematocrit (HCT) 33.03-49.30%), mean corpuscular volume (MCV) 72.83-94.55fl), mean corpuscular hemoglobin (MCH) 23.95-33.55pg, mean corpuscular hemoglobin concentration (MCHC) 32.97-36.7354g/dl, platelet (PLT) count 140.0-418.6×10⁹/l, total white blood cells (WBC) 2.810-8.797 ×10⁹/l and WBC differential count (basophils 0.000-1.000%, neutrophils 30.10-69.17%, eosinophils 1.500-5.000%, lymphocytes 23.86-63.45% and monocytes1.873-5.600%). Significantly higher median values were observed in males compared to females for Hb (P<0.0001), RBC (P<0.0001), HCT (P<0.0001), lymphocyte (P=0.0197) and monocytes (P=0.0009). Contrariwise, females demonstrated significantly higher neutrophils (P=0.0009), eosinophils (P=0.0020), basophils (P<0.0001) and platelets (P=0.0324) than males. This study showed differences in the RVs of CBC compared to those reported in other countries in the Middle East, Asia, Africa, and Europe.

Conclusion: In this study, the reference values of CBC are considered as a benchmark that may assist in accurately judging laboratory results and enhancing medical and clinical services for adults in Ibb City, Yemen.

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确定健康成人全血细胞计数参考值。

背景：全血细胞计数（CBC）通常用于诊断医学评估正常和异常的血液状态。此外，研究者提供的CBC参考值（RVs）是判断阶段最可靠的手段，可以帮助解释和准确诊断疾病。由于生活方式、饮食习惯、种族和环境的差异，参考值因人而异。此外，临床和国际标准协会（CISI）建议确定每个区域的rv。也门没有CBC的房车。因此，本研究旨在确定也门中部伊卜市健康成人CBC的常见RVs。方法：于2023年4月1日至11月30日进行横断面研究。在参与本研究的623名成年人中，433名（18-80岁）在应用排除标准后被纳入最终分析。使用GraphPad Prism 8.0.1计算性别、年龄和居住地的平均、中位数和第95百分位RVs（2.5 -97.5百分位）。结果:血红蛋白（Hb）的RVs为11.16 ~ 17.54g/dl，红细胞（RBC） 3.890-6.340×1012/l，红细胞压积（HCT） 33.03 ~ 49.30%，平均红细胞体积（MCV） 72.83 ~ 94.55fl)，平均红细胞血红蛋白（MCH） 23.95 ~ 33.55pg，平均红细胞血红蛋白浓度（MCHC） 32.97 ~ 36.7354g/dl，血小板（PLT）计数140.0-418.6×109/l，白细胞总数（WBC） 2.81 ~ 8.797 ×109/l和白细胞差异计数(嗜碱性粒细胞0.000 ~ 1.000%，中性粒细胞30.10 ~ 69.17%，嗜酸性粒细胞1.500 ~ 5.000%，淋巴细胞23.86 ~ 63.45%，单核细胞1.873 ~ 5.600%)。男性Hb （PPPP=0.0197）和单核细胞（P=0.0009）的中位数明显高于女性。相反，雌性的中性粒细胞（P=0.0009）、嗜酸性粒细胞（P=0.0020）、嗜碱性粒细胞（PP=0.0324）显著高于雄性。该研究显示，与中东、亚洲、非洲和欧洲其他国家的报告相比，CBC的RVs存在差异。结论：在本研究中，CBC的参考值被认为是一个基准，可以帮助准确判断实验室结果，并加强对也门伊卜市成人的医疗和临床服务。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Blood Medicine HEMATOLOGY-

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： The Journal of Blood Medicine is an international, peer-reviewed, open access, online journal publishing laboratory, experimental and clinical aspects of all topics pertaining to blood based medicine including but not limited to: Transfusion Medicine (blood components, stem cell transplantation, apheresis, gene based therapeutics), Blood collection, Donor issues, Transmittable diseases, and Blood banking logistics, Immunohematology, Artificial and alternative blood based therapeutics, Hematology including disorders/pathology related to leukocytes/immunology, red cells, platelets and hemostasis, Biotechnology/nanotechnology of blood related medicine, Legal aspects of blood medicine, Historical perspectives. Original research, short reports, reviews, case reports and commentaries are invited.