Autistic symptoms and clinical features of individuals at clinical high risk for psychosis and first-episode psychosis

IF 3.8 4区医学 Q1 PSYCHIATRY

Asian journal of psychiatry Pub Date : 2025-01-01 DOI:10.1016/j.ajp.2024.104345

Hiroshi Komatsu , Yutaro Sato , Kazuho Tomimoto , Goh Onoguchi , Tasuku Matsuki , Yumiko Hamaie , Atsushi Sakuma , Noriyuki Ohmuro , Masahiro Katsura , Fumiaki Ito , Takashi Ono , Kazunori Matsumoto , Hiroaki Tomita

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引用次数: 0

Abstract

Introduction

Autistic symptoms in schizophrenia are reportedly associated with cognitive and social functions. However, few studies have investigated the association between autistic symptoms and clinical features in individuals with a clinical high risk for psychosis (CHR-P) and first-episode psychosis (FEP). We aimed to determine the association between autistic symptoms and clinical features in a cohort of individuals with CHR-P or FEP.

Methods

This cross-sectional study included 111 participants (CHR-P: 61, FEP: 50). Autistic symptoms were assessed using the Positive and Negative Syndrome Scale for Schizophrenia Autism Severity Scale. We assessed the association between autistic symptoms and global and social functioning, and cognitive function in individuals with CHR-P or EFP. Multiple regression analysis was also performed using age and sex as covariates to determine the association between autistic symptoms and global functioning.

Results

The participants with FEP had more severe autistic symptoms than those with CHR-P. The results of bivariate correlation analysis showed a significantly negative association of autistic symptoms with global and cognitive functions in both participants with CHR-P and those with FEP. Multiple regression analysis showed that sex, autistic symptoms, and positive symptoms were significant predictors of overall functioning in those participants.

Conclusion

These findings suggest that autistic symptoms are associated with lower global functioning with both individuals at CHR-P and those with FEP. Further longitudinal analysis is needed to characterize the association between autistic symptoms and global functioning in CHR-P and FEP.

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精神病和首发精神病临床高危个体的自闭症症状和临床特征

导读：据报道，精神分裂症患者的自闭症症状与认知和社会功能有关。然而，很少有研究调查具有临床精神病高风险（chrp）和首发精神病（FEP）个体的自闭症症状与临床特征之间的关系。我们旨在确定chrp或FEP患者队列中自闭症症状与临床特征之间的关系。方法：横断面研究纳入111例受试者（chrp: 61, FEP: 50）。使用精神分裂症自闭症严重程度的阳性和阴性综合征量表评估自闭症症状。我们评估了自闭症症状与chrp或EFP患者的整体和社会功能以及认知功能之间的关系。还使用年龄和性别作为协变量进行多元回归分析，以确定自闭症症状与整体功能之间的关联。结果：FEP患者比chrp患者有更严重的自闭症症状。双变量相关分析结果显示，chrp和FEP患者的自闭症症状与整体功能和认知功能呈显著负相关。多元回归分析显示，性别、自闭症症状和阳性症状是这些参与者整体功能的显著预测因子。结论：这些研究结果表明，无论是chrp患者还是FEP患者，自闭症症状都与整体功能低下有关。需要进一步的纵向分析来确定自闭症症状与chrp和FEP的整体功能之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian journal of psychiatry Medicine-Psychiatry and Mental Health

CiteScore

12.70

自引率

5.30%

发文量

297

审稿时长

35 days

期刊介绍： The Asian Journal of Psychiatry serves as a comprehensive resource for psychiatrists, mental health clinicians, neurologists, physicians, mental health students, and policymakers. Its goal is to facilitate the exchange of research findings and clinical practices between Asia and the global community. The journal focuses on psychiatric research relevant to Asia, covering preclinical, clinical, service system, and policy development topics. It also highlights the socio-cultural diversity of the region in relation to mental health.