Black phosphorus nanomaterials mediate size-dependent acute lung injury by promoting macrophage polarization.

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology Pub Date : 2024-12-22 DOI:10.1016/j.fct.2024.115219

Mingtao Wu, Jie Zeng, Wanru Huang, Fengkai Ruan, Zhenghong Zuo, Liang Bu, Chengyong He

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引用次数: 0

Abstract

Black phosphorus nanomaterials (BPNM) exhibit excellent properties and potential applications in electronics, but workers may face inhalation exposure during BPNM production. In addition, there is a lack of biosafety assessments regarding respiratory exposure to BPNM of different sizes. In this study, we investigated the lung toxicity in mice exposed to 5, 50, 500 μg/kg of black phosphorus quantum dots (BPQDs) and black phosphorus nanosheet (BPNS) via single tracheal instillation. The average diameter of the BPQDs and BPNS were 13.48 ± 4.82 nm and 325.53 ± 165.17 nm, respectively. Twenty-four hours after exposure, both BPQDs and BPNS caused acute lung injury, characterized by bronchial wall thickening, alveolar collapse, increased lamellar bodies, and immune cell infiltration. BPNS exposure resulted in reduced gene expression of pulmonary surfactant proteins Spb and Spc. Additionally, both BPQDs and BPNS increased inflammatory factors gene expression and induced lung macrophages polarization, with BPNS demonstrating a more significant effect. This study is the first to show that BPQDs and BPNS induced acute lung injury and inflammation in mice, with BPNS being more toxic. These findings are crucial for enhancing the biosafety assessment of BPNM and advancing technologies to improve the safety of nanomaterials.

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来源期刊

Food and Chemical Toxicology 工程技术-毒理学

CiteScore

10.90

自引率

4.70%

发文量

651

审稿时长

31 days

期刊介绍： Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derived products, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs. The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter. Studies should address at least one of the following: -Adverse physiological/biochemical, or pathological changes induced by specific defined substances -New techniques for assessing potential toxicity, including molecular biology -Mechanisms underlying toxic phenomena -Toxicological examinations of specific chemicals or consumer products, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability. Authors must clearly and briefly identify what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is in the abstract. Furthermore, sufficient doses should be included in order to provide information on NOAEL/LOAEL values.