Long-term exposure to air pollution and lower respiratory infections in a large population-based adult cohort in Catalonia

IF 10.3 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Anna Alari , Otavio Ranzani , Carles Milà , Sergio Olmos , Xavier Basagaña , Payam Dadvand , Talita Duarte-Salles , Mark Nieuwenhuijsen , Cathryn Tonne
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Abstract

Background

Evidence is limited regarding the role of air pollution in acute lower respiratory infections among adults. We assessed the influence of long-term air pollution exposure on hospital admission for lower respiratory infections and whether there are vulnerable subgroups.

Methods

We used a populational cohort in Catalonia, Spain, comprising 3,817,820 adults residing in Catalonia as of January 1, 2015. Air pollution exposure was assigned to individuaĺs residential address using locally-developed models. We characterized the concentration–response functions between long-term air pollution exposure and hospital admission for lower respiratory infections between 2015 and 2019. We assessed interaction between exposure and clinical and socio-economic factors on multiplicative and additive scales.

Results

An interquartile range exposure increase was associated with an 8 % (95 % Confidence Interval: 5 %–11 %) for Nitrogen Dioxide, 10 % (95 % Confidence Interval: 8 %–13 %) for Particulate Matter with diameter equal to or smaller than 2.5 µm, 5 % (95 % Confidence Interval: 3 %–7%) for Particulate Matter with diameter equal to or smaller than 10 µm and 18 % (95 % Confidence Interval: 14 %–22%) for ozone (adjusted by Nitrogen Dioxide) increase in hospital admissions for respiratory infections. Concentration-response functions were non-linear, with steeper slopes at exposures below the median or at most extreme high values. Associations were consistently greater for individuals over 65 years or with hypertension diagnosis and males.

Conclusions

Long-term exposure to air pollution was positively associated with hospital admission for lower respiratory infections. Individuals who were older than 65 years, hypertensive or male were most vulnerable.

Abstract Image

Abstract Image

长期暴露于空气污染和下呼吸道感染在加泰罗尼亚的大型人口为基础的成人队列
关于空气污染在成人急性下呼吸道感染中的作用的证据有限。我们评估了长期空气污染暴露对下呼吸道感染住院的影响,以及是否存在易感亚群。方法我们使用了西班牙加泰罗尼亚的人口队列,包括截至2015年1月1日居住在加泰罗尼亚的3,817,820名成年人。使用当地开发的模型将空气污染暴露分配给individuaĺs住宅地址。我们表征了2015年至2019年长期空气污染暴露与下呼吸道感染住院之间的浓度-响应函数。我们评估了暴露与临床和社会经济因素之间的相互作用。ResultsAn四分位范围暴露增加与8 %(95 %置信区间:-11  % %)二氧化氮,10 %(95 %置信区间:-13  % %)颗粒物的直径等于或小于2.5 µm, 5 %(95 %置信区间:3 % -7%)颗粒物的直径等于或小于10 µm和3 %(95 %置信区间:1 % -5%)对臭氧(调整二氧化氮)增加呼吸道感染住院。浓度-响应函数是非线性的,在暴露低于中位数或最极端的高值时斜率更陡。年龄在65岁 以上的个体和男性之间的关联一直更大。结论长期接触空气污染与下呼吸道感染住院率呈正相关。年龄在65岁 以上的人或男性是最脆弱的。
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来源期刊
Environment International
Environment International 环境科学-环境科学
CiteScore
21.90
自引率
3.40%
发文量
734
审稿时长
2.8 months
期刊介绍: Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.
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