Recent Progress in the Development of Peptide-Drug Conjugates (PDCs) for Cancer Therapy

IF 6 2区医学 Q1 CHEMISTRY, MEDICINAL

European Journal of Medicinal Chemistry Pub Date : 2024-12-24 DOI:10.1016/j.ejmech.2024.117204

Haiqi He, Xin Deng, Zhijie Wang, Jianjun Chen

引用次数: 0

Abstract

Peptide-drug conjugates (PDCs) are emerging therapeutic agents composed of peptides, linkers, and payloads, which possess favorable targeting capability and can deliver enough payloads to the tumor sites with minimized impact on healthy tissues. However, only a few PDCs have been approved for clinical use so far. To advance the research on PDCs, this review summarizes the approved PDCs, and PDCs in clinical and preclinical stages based on the payload types. Additionally, the biological activity and pharmacokinetic properties of preclinical PDCs are detailedly described. Lastly, the challenges and future development directions of PDCs are discussed. This review aims to inspire insights into the development of PDCs for cancer treatment.

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用于癌症治疗的肽-药物偶联物（PDCs）的最新进展

肽-药物偶联物（Peptide-drug conjugates, PDCs）是一种由多肽、连接物和有效载荷组成的新型治疗药物，具有良好的靶向能力，能够在对健康组织影响最小的情况下向肿瘤部位递送足够的有效载荷。然而，到目前为止，只有少数PDCs被批准用于临床。为了进一步推进PDCs的研究，本文根据载荷类型对已批准的PDCs、临床和临床前阶段的PDCs进行了综述。此外，详细描述了临床前PDCs的生物活性和药代动力学特性。最后，讨论了PDCs面临的挑战和未来的发展方向。这篇综述旨在启发人们对肿瘤治疗中PDCs发展的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Medicinal Chemistry 化学-医药化学

CiteScore

11.70

自引率

9.00%

发文量

863

审稿时长

29 days

期刊介绍： The European Journal of Medicinal Chemistry is a global journal that publishes studies on all aspects of medicinal chemistry. It provides a medium for publication of original papers and also welcomes critical review papers. A typical paper would report on the organic synthesis, characterization and pharmacological evaluation of compounds. Other topics of interest are drug design, QSAR, molecular modeling, drug-receptor interactions, molecular aspects of drug metabolism, prodrug synthesis and drug targeting. The journal expects manuscripts to present the rational for a study, provide insight into the design of compounds or understanding of mechanism, or clarify the targets.