Porous Nanocomposite Implants With Gold Nanoparticles for Plastic Surgery

IF 3.9 3区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of biomedical materials research. Part A Pub Date : 2024-12-24 DOI:10.1002/jbm.a.37851

Olena Korotych, Svitlana Dybkova, Anatolii Maletskyi, Liudmyla Rieznichenko, Liudmyla Kernosenko, Tamara Gruzina, Tetiana Poltoratska, Oleksandr Artiomov, Nataliia Pasmurtseva, Valentyna Podolska, Pavlo Vorotytskiy, Yurii Samchenko

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引用次数: 0

Abstract

This study presents an innovative approach to improve implant biointegration and reduce implant-associated infections using porous poly(vinyl formal) nanocomposite matrices incorporated with gold nanoparticles and antimicrobial/anticancer drugs for plastic surgery applications. The porous matrices were characterized using physicochemical techniques and in vitro biochemical assays. The results demonstrated the biocompatibility of PVF nanocomposites and their potential for functionalization with various bioactive molecules and drugs, thereby enhancing their therapeutic efficacy. In vivo studies in rabbits revealed progressive replacement of implants with fibrous tissue, indicating successful biointegration with the surrounding soft tissues. Future research will focus on the long-term biocompatibility and functionalization of these nanocomposite implants for plastic surgery and explore their potential in other biomedical applications such as wound healing, tissue engineering, and scaffolds for cell growth and differentiation.

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用于整形外科的含金纳米颗粒的多孔纳米复合植入物。

本研究提出了一种创新的方法来改善种植体的生物整合和减少种植体相关感染，使用多孔聚（乙烯基）纳米复合基质结合金纳米颗粒和抗菌/抗癌药物用于整形外科应用。采用物理化学技术和体外生化分析对多孔基质进行了表征。结果表明，PVF纳米复合材料具有良好的生物相容性，并具有与多种生物活性分子和药物功能化的潜力，从而提高了其治疗效果。在兔体内的研究显示，纤维组织逐渐替代植入物，表明与周围软组织成功的生物整合。未来的研究将集中在这些纳米复合材料植入物的长期生物相容性和功能化上，并探索其在其他生物医学应用中的潜力，如伤口愈合、组织工程和细胞生长和分化的支架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of biomedical materials research. Part A 工程技术-材料科学：生物材料

CiteScore

10.40

自引率

2.00%

发文量

135

审稿时长

3.6 months

期刊介绍： The Journal of Biomedical Materials Research Part A is an international, interdisciplinary, English-language publication of original contributions concerning studies of the preparation, performance, and evaluation of biomaterials; the chemical, physical, toxicological, and mechanical behavior of materials in physiological environments; and the response of blood and tissues to biomaterials. The Journal publishes peer-reviewed articles on all relevant biomaterial topics including the science and technology of alloys,polymers, ceramics, and reprocessed animal and human tissues in surgery,dentistry, artificial organs, and other medical devices. The Journal also publishes articles in interdisciplinary areas such as tissue engineering and controlled release technology where biomaterials play a significant role in the performance of the medical device. The Journal of Biomedical Materials Research is the official journal of the Society for Biomaterials (USA), the Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Articles are welcomed from all scientists. Membership in the Society for Biomaterials is not a prerequisite for submission.