Post-irradiation Sinus Mucosa Disease in Nasopharyngeal Carcinoma Patients Treated With Proton Therapy.

IF 2.2 3区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Laryngoscope Pub Date : 2024-12-23 DOI:10.1002/lary.31974

Pei-Wen Wu, Chi-Che Huang, Po-Hung Chang, Ta-Jen Lee, Chien-Yu Lin, Joseph Tung-Chieh Chang, Chien-Chia Huang

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引用次数: 0

Abstract

Objective: Post-irradiation sinonasal mucosa disease (SMD) is observed in patients with nasopharyngeal carcinoma (NPC) treated with radiotherapy (RT), leading to a detrimental impact on quality of life. This study aimed to assess the incidence, severity, and regression of the post-irradiation SMD among patients with NPC treated with proton therapy.

Methods: NPC patients treated with proton therapy were retrospectively enrolled. The incidence of SMD was detected using scheduled follow-up magnetic resonance images. The severity of SMD was evaluated using the Lund-Mackay (L-M) staging system. Localized inflammation of the nasopharynx was measured with the endoscopy score.

Results: A total of 161 NPC patients were recruited. The incidence of SMD significantly increased from the third month to the first year after RT. The severity of SMD gradually decreased over time. Regression analyses showed that patients with pre-treatment SMD (OR = 1.75; p = 0.005) and lower serum total protein (OR = 0.16; p = 0.01) were associated with persistence of SMD at 2 years post-RT. Correlations were observed between post-RT L-M and endoscopy scores (r_s = 0.239, p < 0.001). A high endoscopy score (cut-off value, 1.5 [sensitivity, 87.5%; specificity, 49.2%]) predicted the persistence of SMD.

Conclusions: Proton therapy in patients with NPC induces SMD, which peaked at 3 months post-RT, decreased gradually with time, and became insignificant at 2 years post-RT. Pre-existence of SMD and lower serum total protein levels were factors associated with the persistence of post-irradiation SMDs.

Level of evidence: 4 Laryngoscope, 2024.

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来源期刊

Laryngoscope 医学-耳鼻喉科学

CiteScore

6.50

自引率

7.70%

发文量

500

审稿时长

2-4 weeks

期刊介绍： The Laryngoscope has been the leading source of information on advances in the diagnosis and treatment of head and neck disorders since 1890. The Laryngoscope is the first choice among otolaryngologists for publication of their important findings and techniques. Each monthly issue of The Laryngoscope features peer-reviewed medical, clinical, and research contributions in general otolaryngology, allergy/rhinology, otology/neurotology, laryngology/bronchoesophagology, head and neck surgery, sleep medicine, pediatric otolaryngology, facial plastics and reconstructive surgery, oncology, and communicative disorders. Contributions include papers and posters presented at the Annual and Section Meetings of the Triological Society, as well as independent papers, "How I Do It", "Triological Best Practice" articles, and contemporary reviews. Theses authored by the Triological Society’s new Fellows as well as papers presented at meetings of the American Laryngological Association are published in The Laryngoscope. • Broncho-esophagology • Communicative disorders • Head and neck surgery • Plastic and reconstructive facial surgery • Oncology • Speech and hearing defects