Clinical and genetic associations for night eating syndrome in a patient biobank.

IF 3.5 3区 医学 Q2 NUTRITION & DIETETICS
Hannah Wilcox, Richa Saxena, John W Winkelman, Hassan S Dashti
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Abstract

Objective: Night eating syndrome (NES) is an eating disorder characterized by evening hyperphagia. Despite having a prevalence comparable to some other eating disorders, NES remains sparsely investigated and poorly characterized. The present study examined the phenotypic and genetic associations for NES in the clinical Mass General Brigham Biobank.

Method: Cases of NES were identified through relevant billing codes for eating disorders (F50.89/F50.9) and subsequent chart review; patients likely without NES were set as controls. Other diagnoses were determined from billing codes and collapsed into one of 1,857 distinct phenotypes based on clinical similarity. NES associations with diagnoses were systematically conducted in phenome-wide association scans using logistic regression models with adjustments for age, sex, race, and ethnicity. Polygenic scores for six related traits, namely for anorexia nervosa, depression, insomnia, sleep apnea, obesity, and type 2 diabetes were tested for associations with NES among participants of European ancestry using adjusted logistic regression models.

Results: Phenome-wide scans comparing patients with NES against controls (cases n = 88; controls n = 64,539) identified associations with 159 clinical diagnoses spanning 13 broad disease groups including endocrine/metabolic and digestive diseases. Notable associations were evident for bariatric surgery, vitamin D deficiency, sleep disorders (sleep apnea, insomnia, and restless legs syndrome), and attention deficit hyperactivity disorder. The polygenic scores for insomnia and obesity were associated with higher odds of NES (insomnia: odds ratio [OR], 1.24; 95% CI, 1.07, 1.43; obesity: 1.98; 95% CI, 1.71, 2.28).

Discussion: Complementary phenome-wide and genetic exploratory analyses provided information on unique and shared features of NES, offering insights that may facilitate its precise definition, diagnosis, and the development of targeted therapeutic interventions.

患者生物库中夜食综合征的临床和遗传关联。
目的:夜食综合征(NES)是一种以夜间嗜食为特征的进食障碍。尽管NES的患病率与其他一些饮食失调相当,但研究仍然很少,特征也很差。本研究检查了临床Mass General Brigham Biobank中NES的表型和遗传关联。方法:通过进食障碍的相关计费代码(F50.89/F50.9)识别NES病例,随后进行图表审查;可能没有NES的患者作为对照。其他诊断是根据账单代码确定的,并根据临床相似性分解为1857种不同表型之一。在全现象关联扫描中,使用逻辑回归模型对年龄、性别、种族和民族进行调整,系统地研究了NES与诊断的关联。使用调整后的logistic回归模型,对欧洲血统参与者的6个相关特征(即神经性厌食症、抑郁症、失眠、睡眠呼吸暂停、肥胖和2型糖尿病)的多基因评分进行测试,以确定其与NES的关系。结果:全现象扫描将NES患者与对照组进行比较(病例n = 88;对照组n = 64,539)确定了与包括内分泌/代谢和消化疾病在内的13个广泛疾病组的159种临床诊断的相关性。与减肥手术、维生素D缺乏、睡眠障碍(睡眠呼吸暂停、失眠和不宁腿综合征)和注意缺陷多动障碍有明显的关联。失眠和肥胖的多基因评分与NES的较高几率相关(失眠:比值比[OR], 1.24;95% ci, 1.07, 1.43;肥胖:1.98;95% ci, 1.71, 2.28)。讨论:互补的全现象和遗传探索性分析提供了NES独特和共有特征的信息,为其精确定义、诊断和靶向治疗干预的发展提供了见解。
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来源期刊
Journal of Eating Disorders
Journal of Eating Disorders Neuroscience-Behavioral Neuroscience
CiteScore
5.30
自引率
17.10%
发文量
161
审稿时长
16 weeks
期刊介绍: Journal of Eating Disorders is the first open access, peer-reviewed journal publishing leading research in the science and clinical practice of eating disorders. It disseminates research that provides answers to the important issues and key challenges in the field of eating disorders and to facilitate translation of evidence into practice. The journal publishes research on all aspects of eating disorders namely their epidemiology, nature, determinants, neurobiology, prevention, treatment and outcomes. The scope includes, but is not limited to anorexia nervosa, bulimia nervosa, binge eating disorder and other eating disorders. Related areas such as important co-morbidities, obesity, body image, appetite, food and eating are also included. Articles about research methodology and assessment are welcomed where they advance the field of eating disorders.
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