[Development of a method for moxonidine quantification in blood and urine by high-performance liquid chromatography with tandem mass-selective detection].
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引用次数: 0
Abstract
Objective: Development and validation of a sensitive and rapid method for moxonidine detection and quantification in blood and/or urine in clinical toxicology and forensic chemistry.
Material and methods: The method included the following stages: acetonitrile extraction, centrifugation, identification, and quantitative analysis of moxonidine in cadaveric blood and/or urine by high-performance liquid chromatography with a triple quadrupole mass spectrometer.
Results: The method was validated by the following parameters: limit of detection, limit of quantification, linearity, trueness, and precision. Over the entire range of determined concentrations, the relative standard deviation did not exceed 6%.
Conclusion: The obtained results allow future use of this method to detect cases of moxonidine poisoning.
期刊介绍：
The journal is concerned with the theory and practice of forensic medicine - the problems of thanatology, traumatology, toxicology, serology, forensic obstetrics, forensic dentistry, forensic psychiatry, forensic chemistry, physicotechnical methods of investigation, history of forensic medicine and some problems of criminology and legal laws related to forensic medicine. It publishes original studies by Russian authors, casuistry surveys, abstracts and reviews of Russian and foreign literature, scientific information, reports on scientific conferences.
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