Marcus Clarin, Alexandra Hellberg, Kaj Blennow, Ulf Andreasson, Henrik Zetterberg
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引用次数: 0
Abstract
Cerebrospinal fluid (CSF) is routinely investigated to diagnose subarachnoid haemorrhage (SAH) in cases with unclear neuroimaging findings. Using spectrophotometry, the levels of bilirubin and oxyhaemoglobin are analysed. This study investigates the stability for bilirubin and oxyhaemoglobin in CSF samples for up to 3 weeks measured with a spectrophotometer. The absorbances corresponding to bilirubin (455 nm) and oxyhaemoglobin (415 nm) remained fairly stable for up to 3 weeks when samples were stored at +4 °C with light protection. There was a statistically significant trend of decreased absorbance for both oxyhaemoglobin and bilirubin already after exposure to light within 120 min from sampling. It is therefore advisable to protect CSF from light until spectrophotometric analysis.
期刊介绍：
The Scandinavian Journal of Clinical and Laboratory Investigation is an international scientific journal covering clinically oriented biochemical and physiological research. Since the launch of the journal in 1949, it has been a forum for international laboratory medicine, closely related to, and edited by, The Scandinavian Society for Clinical Chemistry.
The journal contains peer-reviewed articles, editorials, invited reviews, and short technical notes, as well as several supplements each year. Supplements consist of monographs, and symposium and congress reports covering subjects within clinical chemistry and clinical physiology.
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