Surgical management of children with Burkitt's lymphoma involving the gastrointestinal tract.

IF 1.5 3区医学 Q2 PEDIATRICS

Pediatric Surgery International Pub Date : 2024-12-23 DOI:10.1007/s00383-024-05955-y

Zhiyi Zhang, Jiayu Yan, Jun Yan, Liuming Huang, Yajun Chen, Xin Ni

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引用次数: 0

Abstract

Purpose: To investigate the clinical characteristics and surgical management of children with Burkitt's lymphoma (BL) involving the gastrointestinal tract.

Methods: A retrospective analysis was conducted on 87 pediatric patients diagnosed with BL involving the gastrointestinal tract and treated surgically at Beijing Children's Hospital (2008-2022). All patients were histopathologically confirmed with BL and diagnosed with gastrointestinal involvement through imaging studies and surgery. Clinical data were reviewed and analyzed.

Results: Among 87 patients, 79 were male and 8 were female, with an average age of 6.8 ± 3.3 years. Predominant clinical manifestations included abdominal pain (74/87, 85.1%) and abdominal mass (45/87, 51.7%). The ileocecal region (31/87, 35.6%) was the most frequent involvement site. The presence of intussusception (58/87, 66.7%) was the main indication for surgery, of which 56 (56/58, 96.6%) underwent enterectomy and anastomosis. Twenty-two (22/87, 25.3%) patients underwent surgery for abdominal mass, with 15 (15/22, 68.2%) receiving an open biopsy. During the follow-up period, 2 patients (2/83, 2.4%) experienced recurrence, 4 patients (4/83, 4.8%) required reoperation, and no deaths were reported.

Conclusion: The main surgical indications for gastrointestinal BL are intussusception and abdominal mass. Surgery plays a crucial role in resolving intussusception, clarifying the diagnosis, and ultimately facilitating the timely initiation of chemotherapy without delay.

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累及胃肠道的伯基特淋巴瘤患儿的外科治疗。

目的：探讨累及胃肠道的儿童伯基特淋巴瘤（Burkitt’s lymphoma， BL）的临床特点及手术治疗。方法：回顾性分析2008-2022年北京儿童医院诊断为累及胃肠道的小儿BL并行手术治疗的87例患儿。所有患者均经组织病理学证实为BL，并通过影像学检查和手术诊断为胃肠道受累。对临床资料进行回顾和分析。结果：87例患者中，男性79例，女性8例，平均年龄6.8±3.3岁。主要临床表现为腹痛（74/87,85.1%）和腹部肿块（45/87,51.7%）。回盲区是最常见的受累部位（31/87,35.6%）。肠套叠（58/87,66.7%）是手术的主要指征，其中56例（56/58,96.6%）行肠切除吻合。22例（22/87,25.3%）患者接受了腹部肿块手术，15例（15/22,68.2%）患者接受了开放式活检。随访期间复发2例（2/83,2.4%），再次手术4例（4/83,4.8%），无死亡病例报告。结论：胃肠道BL的主要手术指征是肠套叠和腹部肿块。手术在解决肠套叠，明确诊断，最终促进及时开始化疗方面起着至关重要的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Surgery International 医学-外科

CiteScore

3.00

自引率

5.60%

发文量

215

审稿时长

3-6 weeks

期刊介绍： Pediatric Surgery International is a journal devoted to the publication of new and important information from the entire spectrum of pediatric surgery. The major purpose of the journal is to promote postgraduate training and further education in the surgery of infants and children. The contents will include articles in clinical and experimental surgery, as well as related fields. One section of each issue is devoted to a special topic, with invited contributions from recognized authorities. Other sections will include: -Review articles- Original articles- Technical innovations- Letters to the editor