A novel placement method of a calibration-free pH capsule for continuous wireless measurement of intragastric pH in horses.

IF 2.6 2区 农林科学
Evelyn Hodgson, Marthe Thirouin, Pranav Narayanan, Tallia-Rume Romano, Jessica Wise, Stephanie Bond
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引用次数: 0

Abstract

Background: Current methods to measure intragastric pH in horses have limitations. A wireless capsule has been designed for continuous esophageal pH monitoring in humans.

Objectives: To (1) determine the feasibility and describe the methodology of measuring intragastric pH wirelessly in horses; and (2) determine attachment duration of the capsules.

Animals: Eleven healthy adult horses.

Methods: Capsules were attached to squamous and glandular gastric mucosa under gastroscopic guidance, using suture loops and 1 to 4 hemostasis clips. pH was continuously recorded using a wireless recorder in both fed and fasted states. Gastroscopy was performed daily to assess capsule attachment and any mucosal damage. Data were analyzed using commercially available software. Values are reported as median (interquartile range).

Results: Capsules were successfully placed and data obtained in squamous (n = 11) and glandular (n = 7) regions. The overall duration of squamous capsule attachment was 27 hours (15-32); 1 clip (n = 4) was 15 hours (11-20), 2 clips (n = 2) was 20 hours (16-23), 3 clips (n = 4) was 32 hours (30-32), and 4 clips (n = 1) was 33 hours. The overall duration of glandular capsule attachment was 10 hours (8-21); 1 clip (n = 2) was 11 hours (10-13), 2 clips (n = 2) was 19 hours (14-23), 3 clips (n = 2) was 7 hours (7-8), and 4 clips (n = 1) was 158 hours. There was no substantial damage to the gastric mucosa as a consequence of attachment.

Conclusions and clinical importance: This novel technique enables the wireless measurement of intragastric pH in horses at known locations under fed and fasted conditions, providing a viable alternative for continuous monitoring in both research and clinical scenarios.

一种用于连续无线测量马胃内pH值的无需校准pH胶囊的新型放置方法。
背景:目前测量马胃内pH值的方法有局限性。一种无线胶囊被设计用于人类食管pH值的连续监测。目的:(1)确定无线测量马胃内pH值的可行性和方法;(2)确定胶囊的附着时间。动物:11匹健康的成年马。方法:在胃镜引导下,用缝线环和1 ~ 4个止血夹将胶囊贴于胃粘膜鳞状和腺状。在进食和禁食状态下,用无线记录仪连续记录pH值。每天进行胃镜检查以评估胶囊附着和任何粘膜损伤。数据分析使用市售软件。数值以中位数(四分位数范围)报告。结果:成功放置胶囊,并在鳞状(n = 11)和腺状(n = 7)区域获得数据。鳞状囊附着的总时间为27小时(15-32);1个夹(n = 4)为15小时(11-20),2个夹(n = 2)为20小时(16-23),3个夹(n = 4)为32小时(30-32),4个夹(n = 1)为33小时。腺囊附着的总时间为10小时(8-21);1个夹(n = 2) 11小时(10-13),2个夹(n = 2) 19小时(14-23),3个夹(n = 2) 7小时(7-8),4个夹(n = 1) 158小时。由于附着,胃粘膜没有实质性的损伤。结论和临床意义:这种新技术可以在已知位置在喂食和禁食条件下无线测量马的胃内pH值,为研究和临床场景的连续监测提供了一种可行的替代方案。
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来源期刊
Journal of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine Veterinary-General Veterinary
自引率
11.50%
发文量
243
期刊介绍: The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.
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