DC algorithm for estimation of sparse Gaussian graphical models.

IF 2.9 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
PLoS ONE Pub Date : 2024-12-23 eCollection Date: 2024-01-01 DOI:10.1371/journal.pone.0315740
Tomokaze Shiratori, Yuichi Takano
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引用次数: 0

Abstract

Sparse estimation of a Gaussian graphical model (GGM) is an important technique for making relationships between observed variables more interpretable. Various methods have been proposed for sparse GGM estimation, including the graphical lasso that uses the ℓ1 norm regularization term, and other methods that use nonconvex regularization terms. Most of these methods approximate the ℓ0 (pseudo) norm by more tractable functions; however, to estimate more accurate solutions, it is preferable to directly use the ℓ0 norm for counting the number of nonzero elements. To this end, we focus on sparse estimation of GGM with the cardinality constraint based on the ℓ0 norm. Specifically, we convert the cardinality constraint into an equivalent constraint based on the largest-K norm, and reformulate the resultant constrained optimization problem into an unconstrained penalty form with a DC (difference of convex functions) representation. To solve this problem efficiently, we design a DC algorithm in which the graphical lasso algorithm is repeatedly executed to solve convex optimization subproblems. Experimental results using two synthetic datasets show that our method achieves results that are comparable to or better than conventional methods for sparse GGM estimation. Our method is particularly advantageous for selecting true edges when cross-validation is used to determine the number of edges. Moreover, our DC algorithm converges within a practical time frame compared to the graphical lasso.

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来源期刊
PLoS ONE
PLoS ONE 生物-生物学
CiteScore
6.20
自引率
5.40%
发文量
14242
审稿时长
3.7 months
期刊介绍: PLOS ONE is an international, peer-reviewed, open-access, online publication. PLOS ONE welcomes reports on primary research from any scientific discipline. It provides: * Open-access—freely accessible online, authors retain copyright * Fast publication times * Peer review by expert, practicing researchers * Post-publication tools to indicate quality and impact * Community-based dialogue on articles * Worldwide media coverage
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