Association between triglyceride-glucose index and its correlation indexes and stress urinary incontinence in postmenopausal women: evidence from NHANES 2005-2018.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2024-12-24 DOI:10.1186/s12944-024-02414-4

Xueping Huang, Wen Hu, Limei Li

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引用次数: 0

Abstract

Background: Postmenopausal women are more susceptible to stress urinary incontinence (SUI), and insulin resistance (IR) is closely related to SUI. The triglyceride-glucose (TyG) index is an efficient metric for assessing IR. Investigating whether TyG index and its correlation indexes were correlated with SUI in postmenopausal women was the aim of this research.

Methods: Data from 2,132 postmenopausal women from the National Health and Nutrition Examination Survey (NHANES) were included in the study for analysis. Weighted multiple logistic regression was used to evaluate the correlation between the TyG index and its correlation indexes and SUI. The nonlinear correlation between the TyG correlation indexes and SUI, as well as the diagnostic efficacy for SUI, was investigated using the smooth curve approach and receiver operating characteristics. Through detailed subgroup analysis, the stability and generalization of the results are confirmed.

Results: Of the 26.87 million, 13.63 million, or 50.73%, suffered from SUI. The prevalence of SUI was significantly higher in the fourth quartile of TyG-BMI (OR = 1.93, 95% CI 1.13-2.84), TyG-WC (OR = 1.76, 95% CI 1.23-2.51), and TyG-WHtR (OR = 1.81, 95% CI 1.28-2.55) compared to the first quartile. Among the three models, TyG-WHtR always maintained a more significant correlation with SUI (Model 1:OR = 1.30;Model 2:OR = 1.33; Model 3:OR = 1.24). Smooth curve fitting results showed that TyG correlation indexes were not linearly correlated with SUI (P > 0.05). Subgroup analysis further confirmed the reliability and applicability of the results. TyG-BMI had the greatest diagnostic performance for SUI out of the four markers.

Conclusions: In comparison to TyG, TyG correlation indexes showed a more significant correlation with SUI among postmenopausal women in US, with TyG-BMI showing the best diagnostic effectiveness.

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绝经后妇女甘油三酯-葡萄糖指数及其相关指标与应激性尿失禁的相关性：来自NHANES 2005-2018的证据

背景：绝经后妇女更易发生应激性尿失禁（SUI），而胰岛素抵抗（IR）与SUI密切相关。甘油三酯-葡萄糖（TyG）指数是评估IR的有效指标。探讨TyG指数及其相关指标是否与绝经后妇女SUI相关是本研究的目的。方法：从国家健康和营养检查调查（NHANES）中纳入2132名绝经后妇女的数据进行分析。采用加权多元logistic回归评价TyG指数及其相关指标与SUI的相关性。采用平滑曲线法和患者工作特征，探讨TyG相关指标与SUI的非线性相关性，以及对SUI的诊断效果。通过详细的子群分析，验证了结果的稳定性和泛化性。结果：2687万人中有1363万人患有SUI，占50.73%。与第一个四分位数相比，TyG-BMI （OR = 1.93, 95% CI 1.13-2.84）、TyG-WC （OR = 1.76, 95% CI 1.23-2.51）和TyG-WHtR （OR = 1.81, 95% CI 1.28-2.55）的第四个四分位数中SUI的患病率明显更高。在三个模型中，TyG-WHtR始终与SUI保持更显著的相关性(模型1:OR = 1.30；模型2:OR = 1.33；模型3:OR = 1.24)。平滑曲线拟合结果显示，TyG相关指标与SUI无线性相关（P < 0.05）。亚组分析进一步证实了结果的可靠性和适用性。在四种指标中，TyG-BMI对SUI的诊断效果最好。结论：与TyG相比，TyG相关指标与美国绝经后妇女SUI的相关性更显著，其中TyG- bmi的诊断效果最好。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.