A new sesquiterpene from the heartwood of Cordia trichotoma (Vell.) Arráb. ex Steud.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-12-24 DOI:10.1080/14786419.2024.2444569

Francisca Roziane Severino Lopes, Francisco das Chagas Lima Pinto, Horlando Carlota da Silva, Francisco Mateus Gomes do Nascimento, Maria Teresa Salles Trevisan, Otília Deusdenia Loiola Pessoa, Gilvandete Maria Pinheiro Santiago

引用次数: 0

Abstract

A new sesquiterpene, 8,11-epoxy-cadi-3,9-diene (1), along with nine known compounds (2-10), were isolated from the heartwood of Cordia trichotoma. Their structures were elucidated based on NMR spectroscopic data, and by comparison with data previously reported in literature. The hexane extract from the heartwood of C. trichotoma, the EtOH extract from the heartwood of C. trichotoma, the CH₂Cl₂-soluble fraction of the EtOH extract, the EtOAc-soluble fraction of the EtOH extract and the compounds 1-6 have been evaluated as acetylcholinesterase inhibitors, and among these, the extracts and fractions exhibited satisfactory results. In addition, compounds 5, 7, and 8 have not been reported previously from this genus.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.