Nanotherapeutics for Macrophage Network Modulation in Tumor Microenvironments: Targets and Tools.

IF 6.6 2区 医学 Q1 NANOSCIENCE & NANOTECHNOLOGY
International Journal of Nanomedicine Pub Date : 2024-12-19 eCollection Date: 2024-01-01 DOI:10.2147/IJN.S491573
Renwei Li, Jing Huang, Yuhao Wei, Yusha Wang, Can Lu, Jifeng Liu, Xuelei Ma
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引用次数: 0

Abstract

Macrophage is an important component in the tumor immune microenvironment, which exerts significant influence on tumor development and metastasis. Due to their dual nature of promoting and suppressing inflammation, macrophages can serve as both targets for tumor immunotherapy and tools for treating malignancies. However, the abundant infiltration of tumor-associated macrophages dominated by an immunosuppressive phenotype maintains a pro-tumor microenvironment, and engineering macrophages using nanotechnology to manipulate the tumor immune microenvironment represent a feasible approach for cancer immunotherapy. Additionally, considering the phagocytic and specifically tumor-targeting capabilities of M1 macrophages, macrophages manipulated through cellular engineering and nanotechnology, as well as macrophage-derived exosomes and macrophage membranes, can also become effective tools for cancer treatment. In conclusion, nanotherapeutics targeting macrophages remains immense potential for the development of macrophage-mediated tumor treatment methods and will further enhance our understanding, diagnosis, and treatment of various malignants.

肿瘤微环境中巨噬细胞网络调节的纳米疗法:靶点和工具。
巨噬细胞是肿瘤免疫微环境的重要组成部分,对肿瘤的发展和转移有重要影响。由于其促进和抑制炎症的双重性质,巨噬细胞既可以作为肿瘤免疫治疗的靶点,也可以作为治疗恶性肿瘤的工具。然而,由免疫抑制表型主导的肿瘤相关巨噬细胞的大量浸润维持了促肿瘤微环境,利用纳米技术操纵肿瘤免疫微环境的工程巨噬细胞代表了一种可行的癌症免疫治疗方法。此外,考虑到M1巨噬细胞的吞噬和特异性肿瘤靶向能力,通过细胞工程和纳米技术操纵的巨噬细胞,以及巨噬细胞来源的外泌体和巨噬细胞膜,也可以成为治疗癌症的有效工具。总之,靶向巨噬细胞的纳米疗法对巨噬细胞介导的肿瘤治疗方法的发展具有巨大的潜力,并将进一步提高我们对各种恶性肿瘤的认识、诊断和治疗。
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来源期刊
International Journal of Nanomedicine
International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY
CiteScore
14.40
自引率
3.80%
发文量
511
审稿时长
1.4 months
期刊介绍: The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.
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