Directed stochasticity: Building biomolecular condensates in the right place.

IF 7.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2025-01-06 Epub Date: 2024-12-24 DOI:10.1083/jcb.202412035

Mark S Geisler, James P Kemp, Robert J Duronio

引用次数: 0

Abstract

Controlling biomolecular condensate formation within the nucleus is critical for genome function. In this issue, Xu et al. (https://doi.org/10.1083/jcb.202401036) report that KPNA3 promotes histone locus body formation and expression of replication-dependent histone genes by both importing NPAT into the nucleus and preventing NPAT condensation from improperly occurring in the cytoplasm.

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定向随机性：在正确的位置构建生物分子凝聚体。

控制核内生物分子凝聚物的形成对基因组功能至关重要。在本期中，Xu等人（https://doi.org/10.1083/jcb.202401036）报道了KPNA3通过将NPAT导入细胞核和防止NPAT在细胞质中不当缩聚，促进组蛋白位点体的形成和复制依赖性组蛋白基因的表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.