The onset presentation of multiple sclerosis differs in Hispanic/Latinx Americans compared with non-Hispanic White Americans.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Multiple Sclerosis Journal Pub Date : 2025-02-01 Epub Date: 2024-12-24 DOI:10.1177/13524585241304976

Farren Bs Briggs, Devon S Conway, Carrie M Hersh, Kathryn C Fitzgerald, Ellen Mowry, Jeffrey A Cohen, Daniel Ontaneda

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引用次数: 0

Abstract

Background: Little is known about how multiple sclerosis (MS) presents in Hispanic/Latinx (HL) people with MS (pwMS).

Objective: Compare age at onset (AAO) and onset severity between HL versus non-Hispanic White (NHW) pwMS.

Methods: A cross-sectional study leveraged the MS PATHS registry spanning seven US tertiary care institutions. HL was subcategorized as HL White (HLW) and HL Other (HLO; all other races). Multivariable models examined relationships between ethnoracial variables and AAO and self-reported presenting disease course. Models were repeated restricting to those born ⩾1970.

Results: The study population included 8231 pwMS, including 540 HL (200 HLW, 340 HLO). The sex distribution did not differ across ethnoracial subgroups. From the statistical models (1) HLO pwMS had an earlier AAO and a higher prevalence of initial progressive disease course than NHW pwMS; (2) among all HL pwMS, irrespective of race, AAO did not differ by sex or between relapsing and progressive MS at onset. In younger HLO adults (born ⩾1970), those with progressive MS at onset had an earlier AAO than those with relapsing MS; and (3) in HL pwMS there was no sex-bias in presenting disease course.

Discussion: Distinct differences in the presentation of MS in HL compared with NHW individuals were observed.

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与非西班牙裔美国白人相比，西班牙裔/拉丁裔美国人多发性硬化症的发病表现不同。

背景：西班牙裔/拉丁裔（HL）多发性硬化症（MS）患者（pwMS）中多发性硬化症（MS）的发病机制尚不清楚。目的：比较HL和非西班牙裔白人pwMS的发病年龄（AAO）和发病严重程度。方法：一项横断面研究利用MS PATHS注册表跨越七个美国三级保健机构。HL又分为白色HL （HLW）和其他HL (HLO；所有其他种族)。多变量模型检验了种族变量与AAO和自我报告的疾病病程之间的关系。模型被重复限制在1970年或以上出生的人。结果：研究人群包括8231例pwMS，其中HL 540例（HLW 200例，HLO 340例）。性别分布在种族亚群之间没有差异。从统计模型来看(1)低水平组患者AAO发生时间早于低水平组，病程初始进展率高于低水平组；(2)在所有HL - pwMS中，无论种族，AAO在性别或复发性和进展性MS发病时均无差异。在年轻的HLO成年人（出生在1970年或以上）中，发病时患有进展性MS的人比复发性MS的人有更早的AAO；(3) HL - pwMS患者在病程表现上无性别差异。讨论：观察到HL与NHW患者在MS表现上的明显差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585