Case Report: A case of infantile acute hyperleukocytic leukemia treated by leukapheresis.

IF 2.1 3区医学 Q2 PEDIATRICS

Frontiers in Pediatrics Pub Date : 2024-12-09 eCollection Date: 2024-01-01 DOI:10.3389/fped.2024.1497943

Shuang Bian, Nannan Li, Hui Gao

引用次数: 0

Abstract

Leukapheresis is a treatment used to reduce leukocytes to decrease the number of white blood cells in circulation and prevent the risks of hyperviscosity and cerebrovascular and pulmonary leukostasis. We present a case of pro-B-cell acute lymphoblastic leukemia (ALL) with hyperleukocytosis in a 6-month-old infant, characterized by a positive KMT2A/AFF1 fusion gene with a leukocyte count of 1,755 × 10⁹/L. After two consecutive sessions of leukapheresis, the white blood cell count decreased to 55 × 10⁹/L. The infant recovered after the high-dose methotrexate chemotherapy. These results demonstrate that leukapheresis is a feasible treatment option for acute hyperleukocytic leukemia in infants with ALL.

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病例报告：1例小儿急性高白细胞白血病经白细胞分离术治疗。

白细胞分离术是一种用于减少白细胞的治疗方法，以减少循环中白细胞的数量，防止高粘稠度、脑血管和肺白细胞停滞的风险。我们报告一例6个月大婴儿的前b细胞急性淋巴细胞白血病（ALL）伴高白细胞增多症，其特征是KMT2A/AFF1融合基因阳性，白细胞计数为1755 × 109/L。连续2次白细胞摘除术后，白细胞计数降至55 × 109/L。婴儿在大剂量甲氨蝶呤化疗后恢复。这些结果表明，白细胞分离术是急性白血病患儿急性高白细胞白血病的一种可行的治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Pediatrics Medicine-Pediatrics, Perinatology and Child Health

CiteScore

3.60

自引率

7.70%

发文量

2132

审稿时长

14 weeks

期刊介绍： Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.