Comprehensive Genetic Analysis Exploring Sedentary Lifestyle, Physical Activity, and Respiratory Diseases: A Bidirectional Mendelian Randomization with Over 500,000 Participants.
Wei Wan, Junhao Tu, Xinyi Huang, Yingxiang Ren, Zhiqiang Zhang, Xinyu Huang, Mengyuan Liu, Yi Qiu, Chunping Yang
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Abstract
Introduction: The associations between sedentary lifestyles, physical activity and the risk of respiratory diseases are crucial areas of medical and health research. Despite numerous studies, uncertainties and controversies regarding causal relationships persist. We utilized Mendelian randomization (MR) analysis, an advanced statistical tool, to further investigate causal links.
Methods: In this study, a bidirectional MR analysis was performed to determine the potential causal relationships between leisure screen time (LST), sedentary behavior at work (SBW), moderate-to-vigorous intensity physical activity during leisure time (MVPA) and 10 common respiratory diseases.
Results: Aggregating outcomes from analytical assessments showed that LST was positively correlated with the risk of asthma (OR = 1.22, 95% CI = 1.10-1.34, p = 9.36E-5), chronic obstructive pulmonary disease (COPD) (OR = 1.31, 95% CI = 1.16-1.49, p = 2.45E-5), lung cancer (OR = 1.18, 95% CI = 1.05-1.32, p = 0.005), and obstructive sleep apnea (OSA) (OR = 1.12, 95% CI = 1.04-1.22, p = 0.003). MVPA was correlated with a reduced risk of developing asthma (OR = 0.68, 95% CI = 0.53-0.88, p = 0.004) and COPD (OR = 0.62, 95% CI = 0.47-0.83, p = 0.001). A genetic predisposition to SBW was associated with a decreased risk of nasal polyps (OR = 0.60, 95% CI = 0.423-0.86, p = 0.005).
Conclusion: Our findings demonstrate complex causal relationships between sedentary lifestyles, physical activity and various respiratory system diseases. These discoveries hold significant value in devising precision-oriented approaches for the prevention and treatment of respiratory system diseases.
久坐不动的生活方式、体力活动和呼吸系统疾病风险之间的联系是医学和健康研究的重要领域。尽管有大量的研究，关于因果关系的不确定性和争议仍然存在。我们利用孟德尔随机化（MR）分析，一种先进的统计工具，进一步调查因果关系。方法：本研究采用双向磁共振分析来确定休闲屏幕时间（LST）、工作中久坐行为（SBW）、休闲时间中高强度体力活动（MVPA）与10种常见呼吸系统疾病之间的潜在因果关系。结果：分析性评估的综合结果显示，LST与哮喘（OR = 1.22, 95% CI = 1.10-1.34, p = 9.36E-5）、慢性阻塞性肺疾病（COPD） （OR = 1.31, 95% CI = 1.16-1.49, p = 2.45E-5）、肺癌（OR = 1.18, 95% CI = 1.05-1.32, p = 0.005）和阻塞性睡眠呼吸暂停（OSA） （OR = 1.12, 95% CI = 1.04-1.22, p = 0.003）的风险呈正相关。MVPA与哮喘（OR = 0.68, 95% CI = 0.53-0.88, p = 0.004）和COPD （OR = 0.62, 95% CI = 0.47-0.83, p = 0.001）发生风险降低相关。SBW的遗传易感性与鼻息肉风险降低相关（OR = 0.60, 95% CI = 0.423-0.86, p = 0.005）。结论：我们的研究结果表明，久坐的生活方式、体育活动和各种呼吸系统疾病之间存在复杂的因果关系。这些发现对于设计精确的呼吸系统疾病预防和治疗方法具有重要价值。
期刊介绍：
''International Archives of Allergy and Immunology'' provides a forum for basic and clinical research in modern molecular and cellular allergology and immunology. Appearing monthly, the journal publishes original work in the fields of allergy, immunopathology, immunogenetics, immunopharmacology, immunoendocrinology, tumor immunology, mucosal immunity, transplantation and immunology of infectious and connective tissue diseases.
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