Associations between ethylene oxide exposure and chronic bronchitis: results from the NHANES 2013-2018.

IF 3 3区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Frontiers in Public Health Pub Date : 2024-12-09 eCollection Date: 2024-01-01 DOI:10.3389/fpubh.2024.1424555
Yan Li, Hui Wang, Xiaoqing Bi, Guowei Zhao
{"title":"Associations between ethylene oxide exposure and chronic bronchitis: results from the NHANES 2013-2018.","authors":"Yan Li, Hui Wang, Xiaoqing Bi, Guowei Zhao","doi":"10.3389/fpubh.2024.1424555","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Ethylene oxide (EtO) is a reactive gas commonly used in the production of various chemical compounds. Research has linked EtO exposure to respiratory conditions, including chronic obstructive pulmonary disease (COPD) and asthma. However, its potential effects on chronic bronchitis (CB) remain unclear, highlighting the need for further study to understand its role in respiratory health.</p><p><strong>Methods: </strong>Our study investigated data from 5,044 NHANES participants between 2013 and 2018 across three 2-year survey cycles. The relationship between HbEtO and CB was examined using weighted logistic regression, with HbEtO quartiles analyzed to assess the trend. A smoothed curve was fitted to verify the relationship between HbEtO and CB. Additionally, sensitivity analyses were conducted to assess the robustness of our results, while subgroup analyses explored potential effect modifiers of the HbEtO-CB association.</p><p><strong>Results: </strong>Compared with patients without CB, patients with CB had elevated HbEtO levels. Specifically, natural Log<sub>2</sub>HbEtO levels were linked to a greater prevalence of CB in a fully adjusted model (OR = 1.243, 95% CI: 1.143-1.352). Analysis of Log<sub>2</sub>HbEtO quartiles showed a significant trend in Q4 compared with Q1 (<i>p</i> for trend < 0.001). The fitted smoothed curve indicated a U-shaped nonlinear association, with saturation and threshold analysis revealing an inflection point at Log<sub>2</sub>HbEtO = 4.87. Sensitivity analyses confirmed the robustness of these findings, and subgroup analyses identified consistent associations across various groups.</p><p><strong>Conclusion: </strong>Our study found a significant association between EtO exposure and the occurrence of CB. Given the health risks linked to EtO exposure, implementing effective control measures is essential. Such actions could help lower CB prevalence and enhance respiratory health in vulnerable populations.</p>","PeriodicalId":12548,"journal":{"name":"Frontiers in Public Health","volume":"12 ","pages":"1424555"},"PeriodicalIF":3.0000,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663886/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Public Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fpubh.2024.1424555","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: Ethylene oxide (EtO) is a reactive gas commonly used in the production of various chemical compounds. Research has linked EtO exposure to respiratory conditions, including chronic obstructive pulmonary disease (COPD) and asthma. However, its potential effects on chronic bronchitis (CB) remain unclear, highlighting the need for further study to understand its role in respiratory health.

Methods: Our study investigated data from 5,044 NHANES participants between 2013 and 2018 across three 2-year survey cycles. The relationship between HbEtO and CB was examined using weighted logistic regression, with HbEtO quartiles analyzed to assess the trend. A smoothed curve was fitted to verify the relationship between HbEtO and CB. Additionally, sensitivity analyses were conducted to assess the robustness of our results, while subgroup analyses explored potential effect modifiers of the HbEtO-CB association.

Results: Compared with patients without CB, patients with CB had elevated HbEtO levels. Specifically, natural Log2HbEtO levels were linked to a greater prevalence of CB in a fully adjusted model (OR = 1.243, 95% CI: 1.143-1.352). Analysis of Log2HbEtO quartiles showed a significant trend in Q4 compared with Q1 (p for trend < 0.001). The fitted smoothed curve indicated a U-shaped nonlinear association, with saturation and threshold analysis revealing an inflection point at Log2HbEtO = 4.87. Sensitivity analyses confirmed the robustness of these findings, and subgroup analyses identified consistent associations across various groups.

Conclusion: Our study found a significant association between EtO exposure and the occurrence of CB. Given the health risks linked to EtO exposure, implementing effective control measures is essential. Such actions could help lower CB prevalence and enhance respiratory health in vulnerable populations.

环氧乙烷暴露与慢性支气管炎之间的关系:NHANES 2013-2018的结果。
简介:环氧乙烷(EtO)是一种常用于各种化合物生产的反应性气体。研究表明,接触电子烟与呼吸系统疾病有关,包括慢性阻塞性肺疾病(COPD)和哮喘。然而,其对慢性支气管炎(CB)的潜在影响尚不清楚,因此需要进一步研究以了解其在呼吸系统健康中的作用。方法:我们的研究调查了2013年至2018年期间5044名NHANES参与者的数据,调查周期为3个2年。采用加权逻辑回归检验HbEtO与CB之间的关系,并分析HbEtO四分位数以评估趋势。拟合了一条平滑曲线来验证HbEtO与CB之间的关系。此外,我们还进行了敏感性分析以评估结果的稳健性,而亚组分析则探讨了HbEtO-CB关联的潜在影响调节因素。结果:与无CB患者相比,CB患者HbEtO水平升高。具体而言,在完全调整的模型中,天然Log2HbEtO水平与更大的CB患病率相关(OR = 1.243, 95% CI: 1.143-1.352)。Log2HbEtO四分位数分析显示,与第一季度相比,第四季度有显著趋势(p < 0.001)。拟合的光滑曲线呈u形非线性关联,饱和和阈值分析显示在Log2HbEtO = 4.87处出现拐点。敏感性分析证实了这些发现的稳健性,亚组分析确定了不同组之间的一致关联。结论:我们的研究发现EtO暴露与炭黑的发生有显著的关联。鉴于与接触电子烟有关的健康风险,实施有效的控制措施至关重要。此类行动可有助于降低易受伤害人群的CB患病率并增进呼吸系统健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Frontiers in Public Health
Frontiers in Public Health Medicine-Public Health, Environmental and Occupational Health
CiteScore
4.80
自引率
7.70%
发文量
4469
审稿时长
14 weeks
期刊介绍: Frontiers in Public Health is a multidisciplinary open-access journal which publishes rigorously peer-reviewed research and is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians, policy makers and the public worldwide. The journal aims at overcoming current fragmentation in research and publication, promoting consistency in pursuing relevant scientific themes, and supporting finding dissemination and translation into practice. Frontiers in Public Health is organized into Specialty Sections that cover different areas of research in the field. Please refer to the author guidelines for details on article types and the submission process.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信