The impact of surgery with general anesthesia on cognitive function and putamen volume: a cross-sectional study among older adults.

IF 4.1 2区医学 Q2 GERIATRICS & GERONTOLOGY

Frontiers in Aging Neuroscience Pub Date : 2024-12-09 eCollection Date: 2024-01-01 DOI:10.3389/fnagi.2024.1483989

Jianjun Jiang, Zhuyun Zhang, Hong Zheng, Jian Lu, Wei Li

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引用次数: 0

Abstract

Background: Previous studies have shown that surgery under general anesthesia may diminish cognitive function; however, the proposed mechanisms need further elucidation. The purpose of the current study was twofold: (1) to compare overall and domain-specific differences in cognitive function between the surgery under general anesthesia group and the control group, and (2) to investigate the possible mechanisms of surgery under general anesthesia affecting cognitive function, using T1-structural magnetic resonance imaging.

Methods: A total of 194 older adults were included in this study. Patients were divided into a surgery under general anesthesia group (n = 92) and a control group (n = 104). The two groups were matched for age, sex, and educational level. All participants underwent clinical evaluation, neuropsychological testing, blood biochemistry analysis, and T1 phase structural magnetic resonance imaging.

Results: We found that older adults with a history of surgery under general anesthesia had lower Montreal Cognitive Assessment (MoCA) scores and smaller right putamen volumes (p < 0.05). Linear regression analysis (mediation model) indicated that surgery under general anesthesia affected MoCA scores by diminishing the volume of the right putamen (B = 1.360, p = 0.030).

Conclusion: We found evidence that older adults who underwent surgery under general anesthesia had poorer cognitive function, which may have been caused by an apoptotic or otherwise toxic effect of anesthetic drugs on the volume of the right putamen.

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全麻手术对老年人认知功能和壳核体积的影响：一项横断面研究。

背景：先前的研究表明，全身麻醉下的手术可能会降低认知功能；然而，所提出的机制需要进一步阐明。本研究的目的有两个：(1)比较全麻手术组与对照组认知功能的整体和特定领域差异；(2)利用t1结构磁共振成像探讨全麻手术影响认知功能的可能机制。方法：本研究共纳入194名老年人。将患者分为全麻手术组（n = 92）和对照组（n = 104）。这两组在年龄、性别和教育程度上都是匹配的。所有参与者进行了临床评估、神经心理测试、血液生化分析和T1期结构磁共振成像。结果：我们发现有全麻手术史的老年人蒙特利尔认知评估（MoCA）评分较低，右侧壳核体积较小（p p = 0.030）。结论：我们发现在全身麻醉下接受手术的老年人认知功能较差，这可能是由于麻醉药物对右侧壳核体积的凋亡或其他毒性作用所致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES

CiteScore

6.30

自引率

8.30%

发文量

1426

期刊介绍： Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.