Association between psychiatric symptoms with multiple peripheral blood sample test: a 10-year retrospective study.

IF 3.2 3区 医学 Q2 PSYCHIATRY
Frontiers in Psychiatry Pub Date : 2024-12-09 eCollection Date: 2024-01-01 DOI:10.3389/fpsyt.2024.1481006
Jianqing Qiu, Cheng Yu, Yalan Kuang, Yao Hu, Ting Zhu, Ke Qin, Wei Zhang
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引用次数: 0

Abstract

Background: Psychiatric illness is thought to be a brain somatic crosstalk disorder. However, the existing phenomenology-based Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic framework overlooks various dimensions other than symptoms. In this study, we investigated the associations between peripheral blood test indexes with various symptom levels of major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) to explore the availability of peripheral blood test indexes.

Methods: We extracted cases diagnosed with MDD, BD, and SCZ at West China Hospital from 2009 to 2021, translated their main complaints into Research Domain Criteria (RDoC) symptom severity scores using nature language processing (NLP), and collected their detailed psychiatric symptoms and peripheral blood test results. Then, generalized linear models were performed between seven types of peripheral blood test values with their transformed RDoC scores and detailed symptom information adjusted for age, gender, smoking, and alcohol history.

Results: Several inflammatory-related indexes were strongly associated with the negative valence system (NVS) domain (basophil percentage adjusted β = 0.275, lymphocyte percentage adjusted β = 0.271, monocyte percentage adjusted β = 0.223, neutrophil percentage adjusted β = -0.310, neutrophil count adjusted β = -0.301, glucose adjusted β = -0.287, leukocyte count adjusted β = -0.244, NLR adjusted β = -0.229, and total protein adjusted β = -0.170), the positive valence system (PVS) domain (monocyte percentage adjusted β = 0.228, basophil count adjusted β = 0.176, and glutamyl transpeptidase adjusted β = 0.171), and a wide range of mood, reward, and psychomotor symptoms. In addition, glucose, urea, urate, cystatin C, and albumin showed considerable associations with multiple symptoms. In addition, based on the direction of associations and the similarity of symptoms in terms of RDoC thinking, it is suggested that "positive" mood symptoms like mania and irritability and "negative" mood symptoms like depression and anxiety might be on a continuum considering their opposite relationships with similar blood indexes.

Limitations: The cross-sectional design, limited symptoms record, and high proportion of missing values in some other peripheral blood indexes limited our findings.

Conclusion: The proportion of high inflammatory indexes in SCZ was relatively high, but in terms of mean values, SCZ, BD, and MDD did not differ significantly. Inflammatory response showed a strong correlation with NVS, PVS, and a range of psychiatric symptoms especially mood symptoms, psychomotor symptoms, and cognitive abilities.

精神症状与多种外周血样本检测之间的关系:一项为期 10 年的回顾性研究。
背景:精神疾病被认为是一种脑躯体相声障碍。然而,现有的基于现象学的《精神障碍诊断与统计手册》第五版(DSM-5)诊断框架忽略了症状以外的其他维度。在这项研究中,我们研究了外周血检查指标与重度抑郁症(MDD)、双相情感障碍(BD)和精神分裂症(SCZ)不同症状水平的关系,以探讨外周血检查指标的可用性。方法:选取2009 - 2021年华西医院诊断为MDD、BD和SCZ的病例,采用自然语言处理(NLP)将其主诉转化为研究领域标准(RDoC)症状严重程度评分,收集其详细的精神症状和外周血检查结果。然后,在7种类型的外周血检查值与转换后的RDoC评分和根据年龄、性别、吸烟和饮酒史调整的详细症状信息之间建立广义线性模型。结果:多个炎症相关指标与NVS结构域密切相关(嗜碱性粒细胞百分比调节β = 0.275,淋巴细胞百分比调节β = 0.271,单核细胞百分比调节β = 0.223,中性粒细胞百分比调节β = -0.310,中性粒细胞计数调节β = -0.301,葡萄糖调节β = -0.287,白细胞计数调节β = -0.244, NLR调节β = -0.229,总蛋白调节β = -0.170)。正价系统(PVS)结构域(单核细胞百分比调节β = 0.228,嗜碱性粒细胞计数调节β = 0.176,谷氨酰转肽酶调节β = 0.171),以及广泛的情绪、奖励和精神运动症状。此外,葡萄糖、尿素、尿酸、胱抑素C和白蛋白与多种症状有相当大的相关性。此外,从RDoC思维的关联方向和症状的相似性来看,躁狂、易怒等“积极”情绪症状与抑郁、焦虑等“消极”情绪症状的反向关系与相似的血液指标可能是一个连续体。局限性:横断面设计,有限的症状记录,以及其他一些外周血指标的高缺失率限制了我们的发现。结论:SCZ中炎性指数高的比例较高,但SCZ、BD、MDD的平均值差异无统计学意义。炎症反应与NVS、PVS和一系列精神症状,特别是情绪症状、精神运动症状和认知能力密切相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers in Psychiatry
Frontiers in Psychiatry Medicine-Psychiatry and Mental Health
CiteScore
6.20
自引率
8.50%
发文量
2813
审稿时长
14 weeks
期刊介绍: Frontiers in Psychiatry publishes rigorously peer-reviewed research across a wide spectrum of translational, basic and clinical research. Field Chief Editor Stefan Borgwardt at the University of Basel is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. The journal''s mission is to use translational approaches to improve therapeutic options for mental illness and consequently to improve patient treatment outcomes.
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