Macrophage metabolic reprogramming: A trigger for cardiac damage in autoimmune diseases

IF 9.2 1区医学 Q1 IMMUNOLOGY

Autoimmunity reviews Pub Date : 2024-12-21 DOI:10.1016/j.autrev.2024.103733

Lin Liu , Minghao Li , Chunyu Zhang , Yi Zhong , Bin Liao , Jian Feng , Li Deng

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Abstract

Macrophage metabolic reprogramming has a central role in the progression of autoimmune and auto-inflammatory diseases. The heart is a major target organ in many autoimmune conditions and can sustain functional and structural impairments, potentially leading to irreversible cardiac damage. There is mounting clinical evidence pointing to a link between autoimmune disease and cardiac damage. However, this association remains poorly understood, and numerous patients do not receive appropriate preventive measures, which poses serious cardiovascular risks and significantly impacts their quality of life. This review discusses the relationship between macrophage metabolic reprogramming and cardiac damage in patients with autoimmune diseases and the role of adaptive immunity in macrophage reprogramming. It also provides an overview of the immunosuppressive therapies used at present. Exploiting the properties of macrophage reprogramming could lead to development of novel treatments for patients with autoimmune-related cardiac damage.

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巨噬细胞代谢重编程：自身免疫性疾病心脏损伤的触发因素。

巨噬细胞代谢重编程在自身免疫性和自身炎症性疾病的进展中起核心作用。心脏是许多自身免疫性疾病的主要靶器官，可以维持功能和结构损伤，可能导致不可逆的心脏损伤。越来越多的临床证据表明自身免疫性疾病和心脏损伤之间存在联系。然而，这种关联仍然知之甚少，许多患者没有接受适当的预防措施，这造成了严重的心血管风险，并显著影响了他们的生活质量。本文就自身免疫性疾病患者巨噬细胞代谢重编程与心脏损伤的关系以及适应性免疫在巨噬细胞重编程中的作用进行综述。它还提供了目前使用的免疫抑制疗法的概述。利用巨噬细胞重编程的特性可以为自身免疫性心脏损伤患者提供新的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autoimmunity reviews 医学-免疫学

CiteScore

24.70

自引率

4.40%

发文量

164

审稿时长

21 days

期刊介绍： Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.