Tenofovir-associated Fanconi Syndrome in liver transplant recipients with hepatitis B: A retrospective case series.

Abstract

Tenofovir-associated Fanconi Syndrome (TAFS) is a proximal renal tubule disorder rarely reported in patients after liver transplantation (LT) for hepatitis B (HBV). In a retrospective review of 79 HBV-LT recipients, 8/66 (12.1%) on tenofovir post-LT developed TAFS. Primary laboratory findings were hypophosphatemia (100%) and proteinuria (87.5%). No patients required renal replacement therapy or died from TAFS. The majority (85.7%) of surviving patients achieved tubular recovery after stopping tenofovir (mean 13 weeks). In conclusion, TAFS is likely underdiagnosed in LT recipients. Regular screening for hypophosphatemia, proteinuria, and glucosuria is recommended for HBV-LT recipients on tenofovir, as most responded well to discontinuation.