{"title":"Significant differences in knee kinematics of healthy subjects with high and low anterior tibial laxity.","authors":"Shiyang Chen, Shaohua Chen, Qingyang Kang, Fangzheng Lin, Shuting Zheng, Xixi Liu, Chunhong Guo, Yongjin Li, Dingkun Lin, Xiaolong Zeng","doi":"10.3389/fbioe.2024.1514516","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Anterior tibial laxity is considered to be a risk factor for knee injuries, including anterior cruciate ligament ruptures. The anterior cruciate ligament reconstruction also aims to restore anterior tibial laxity. While anterior tibial laxity is considered to be linked to dynamic knee stability, the mechanisms connecting anterior tibial laxity to these stability issues are not fully understood. The purpose of this study was to investigate the kinematic alterations between different anterior tibial laxity in healthy subjects. We hypothesized that anterior tibial laxity affects the anteroposterior tibial displacement during dynamic movements.</p><p><strong>Methods: </strong>This study involved thirty-five healthy subjects. There were twenty males and fifteen females with an average age of 18.91 ± 0.78 years. Their knees were categorized into \"Tight\" (the smallest 50%) and \"Lax\" (the largest 50%) groups based on anterior tibial laxity measurements using a Kneelax3 arthrometer. Kinematic data were collected using a three-dimensional motion capture system when they performed level walking, upslope walking, and vertical jumping. The knee kinematics were recorded for statistical analysis. We used independent sample t-tests to analyze key kinematic differences between groups.</p><p><strong>Results: </strong>The \"Lax\" group exhibited increased posterior tibial translation during upslope walking (5.4 ± 2.22 mm at swing max flexion, <i>p</i> = 0.018) and vertical jumping (8.5 ± 2.78 mm at propulsion max flexion, <i>p</i> = 0.003; 7.6 ± 3.17 mm at landing max flexion, <i>p</i> = 0.019) than the \"Tight\" group. Significant differences in tibial internal rotation were observed during initial contact of the gait cycle of level walking (1.9° ± 0.95°, <i>p</i> = 0.049) and upslope walking (2.1° ± 1.03°, <i>p</i> = 0.041) in the \"Lax\" group compared to the \"Tight\" group. No significant differences in adduction/abduction or medial/lateral tibial translation were found between groups.</p><p><strong>Conclusion: </strong>The study revealed that high anterior tibial laxity resulted in increased posterior tibial translation and tibial internal rotation. High anterior tibial laxity resulted in dynamic instability of knees during motions, especially in high-demanding activities like upslope or vertical jumping. However, further research is needed to explore the clinical functional effects of knee laxity.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"12 ","pages":"1514516"},"PeriodicalIF":4.3000,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664222/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Bioengineering and Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3389/fbioe.2024.1514516","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Anterior tibial laxity is considered to be a risk factor for knee injuries, including anterior cruciate ligament ruptures. The anterior cruciate ligament reconstruction also aims to restore anterior tibial laxity. While anterior tibial laxity is considered to be linked to dynamic knee stability, the mechanisms connecting anterior tibial laxity to these stability issues are not fully understood. The purpose of this study was to investigate the kinematic alterations between different anterior tibial laxity in healthy subjects. We hypothesized that anterior tibial laxity affects the anteroposterior tibial displacement during dynamic movements.
Methods: This study involved thirty-five healthy subjects. There were twenty males and fifteen females with an average age of 18.91 ± 0.78 years. Their knees were categorized into "Tight" (the smallest 50%) and "Lax" (the largest 50%) groups based on anterior tibial laxity measurements using a Kneelax3 arthrometer. Kinematic data were collected using a three-dimensional motion capture system when they performed level walking, upslope walking, and vertical jumping. The knee kinematics were recorded for statistical analysis. We used independent sample t-tests to analyze key kinematic differences between groups.
Results: The "Lax" group exhibited increased posterior tibial translation during upslope walking (5.4 ± 2.22 mm at swing max flexion, p = 0.018) and vertical jumping (8.5 ± 2.78 mm at propulsion max flexion, p = 0.003; 7.6 ± 3.17 mm at landing max flexion, p = 0.019) than the "Tight" group. Significant differences in tibial internal rotation were observed during initial contact of the gait cycle of level walking (1.9° ± 0.95°, p = 0.049) and upslope walking (2.1° ± 1.03°, p = 0.041) in the "Lax" group compared to the "Tight" group. No significant differences in adduction/abduction or medial/lateral tibial translation were found between groups.
Conclusion: The study revealed that high anterior tibial laxity resulted in increased posterior tibial translation and tibial internal rotation. High anterior tibial laxity resulted in dynamic instability of knees during motions, especially in high-demanding activities like upslope or vertical jumping. However, further research is needed to explore the clinical functional effects of knee laxity.
背景：胫骨前松弛被认为是膝关节损伤的危险因素，包括前交叉韧带断裂。前交叉韧带重建也旨在恢复胫骨前松弛。虽然胫骨前松弛被认为与动态膝关节稳定性有关，但将胫骨前松弛与这些稳定性问题联系起来的机制尚不完全清楚。本研究的目的是探讨健康受试者不同胫骨前松弛度之间的运动学改变。我们假设在动态运动中，胫骨前松弛影响胫骨前后移位。方法：本研究纳入35名健康受试者。男性20例，女性15例，平均年龄18.91±0.78岁。根据使用膝关节计测量的胫骨前松弛度，将他们的膝盖分为“紧”（最小的50%）和“松”（最大的50%）两组。在水平行走、上坡行走和垂直跳跃时，使用三维运动捕捉系统收集运动学数据。记录膝关节运动学进行统计分析。我们使用独立样本t检验来分析各组之间的关键运动学差异。结果：“Lax”组在上坡行走（摆动最大屈曲时5.4±2.22 mm, p = 0.018）和垂直跳跃（推进最大屈曲时8.5±2.78 mm, p = 0.003）时胫骨后平移增加；（7.6±3.17 mm, p = 0.019）。在水平行走（1.9°±0.95°，p = 0.049）和上坡行走（2.1°±1.03°，p = 0.041）的步态周期初始接触时，“Lax”组与“Tight”组的胫骨内旋有显著差异。两组间内收/外展或胫骨内侧/外侧平移均无显著差异。结论：胫骨前高度松弛导致胫骨后移位和胫骨内旋增加。胫骨前高度松弛导致膝关节在运动中动态不稳定，特别是在高要求的活动中，如上坡或垂直跳跃。然而，膝关节松弛对临床功能的影响还需要进一步的研究。
期刊介绍：
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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