Robot-Assisted Synthesis of Structure-Controlled Star-Cluster Hydrogels with Targeted Mechanophysical Properties for Biomedical Applications.

IF 5.5 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2024-12-23 DOI:10.1021/acs.biomac.4c01148

Vianna F Jafari, Shirin Nour, Ross A L Wylie, Daniel E Heath, Greg G Qiao

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引用次数: 0

Abstract

Advancements in polymer chemistry have enabled the design of macromolecular structures with tailored properties for diverse applications. Reversible addition-fragmentation chain-transfer (RAFT) polymerization is a controlled technique for precise polymer design. Automation tools further enhance polymer synthesis by enabling the rapid, reproducible preparation of polymer libraries. This study utilizes an automated platform and a biologically friendly bio-Fenton RAFT synthesis method to create hydrogels with embedded star polymers derived from complex block copolymers with controlled block lengths and sequences. Automation improves the efficiency compared to manual methods, while the choice of prepolymer and polymerization techniques ensures biocompatibility. Hydrogels formed by cross-linking linear block copolymers exhibit tunable physical, chemical, and mechanical properties. By systematically altering the prepolymer block sequences, promising hydrogel candidates for enhanced cell biocompatibility and proliferation are identified. These synthetic hydrogels mimic cellular microenvironments and offer a robust platform for biomedical applications, paving the way for an efficient hydrogel design and synthesis.

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.