NIR-II upconversion nanomaterials for biomedical applications

IF 5.8 3区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Nanoscale Pub Date : 2024-12-24 DOI:10.1039/d4nr04445b
Ranran Luo, Chenxi Zhang, Zening Zhang, Pengchen Ren, Zhongsheng Xu, Yun Liu
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引用次数: 0

Abstract

As a nonlinear optical phenomenon, upconversion (UC) occurs when two or more low-energy excitation photons are sequentially absorbed and emitted. Upconversion nanomaterials exhibit superior photostability, non-invasiveness, a unique near-infrared anti-Stokes shift, and enhanced tissue penetration capability. However, general upconversion nanomaterials typically utilize visible light (400–700 nm) for excitation, leading to limited tissue penetration, background signal interference, limited excitation efficiency and imaging quality issues due to tissue absorption and scattering. The increasing use of upconversion nanomaterials in the near-infrared one-region (NIR-I) window (700–900 nm) offers benefits such as enhanced penetration into biological tissues, relatively improved imaging resolution, and lower spontaneous luminescence, although these materials are still susceptible to background signals, limiting their effectiveness in high signal-to-noise ratio imaging. This distinctive wavelength conversion endows upconversion nanomaterials in the NIR-II region with extraordinary potential for diverse applications. Biomedical research has primarily focused on biomedical imaging for disease diagnosis and treatment, as well as biomarker detection. Nonetheless, studies specifically targeting the NIR-II window remain limited. This paper summarizes the latest research progress on upconversion nanomaterials in the NIR-II region. It begins by introducing the preparation methods for these materials in the NIR-II, followed by their applications in imaging and biological contexts. Lastly, it discusses the primary challenges and future prospects of upconversion materials in NIR-II, aiming to promote their development.

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来源期刊
Nanoscale
Nanoscale CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
12.10
自引率
3.00%
发文量
1628
审稿时长
1.6 months
期刊介绍: Nanoscale is a high-impact international journal, publishing high-quality research across nanoscience and nanotechnology. Nanoscale publishes a full mix of research articles on experimental and theoretical work, including reviews, communications, and full papers.Highly interdisciplinary, this journal appeals to scientists, researchers and professionals interested in nanoscience and nanotechnology, quantum materials and quantum technology, including the areas of physics, chemistry, biology, medicine, materials, energy/environment, information technology, detection science, healthcare and drug discovery, and electronics.
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