Effect of Olanzapine on Hyperemesis Gravidarum in Individuals With Mood Disorders: A Case Series

Abstract

This case series examines the effect of olanzapine on symptoms of hyperemesis gravidarum in individuals with mood disorders. Patient charts from 2022 to 2024 were reviewed, focusing on those with hyperemesis gravidarum who were treated with olanzapine alone or with other psychotropic drugs for their mood disorder. Of 6 patients with hyperemesis gravidarum, 3 had bipolar II disorder, and the others had major depressive disorder. Olanzapine was used alone in 3 cases. A daily dose of 2.5–5 mg was well tolerated and effective in all patients who had failed trials of conventional antiemetics. Thus, olanzapine may be a viable treatment for hyperemesis gravidarum in mood disorder patients unresponsive to standard antiemetics.