The relationship between HER2 status acquired from pathological data and metabolic parameters from pre-treatment [18F]FDG PET/CT in gastric adenocarcinomas.

M N Acar Tayyar, M Ö Tamam, G B Babacan, M C Şahin, H Özçevik, S Şengiz Erhan, A E Öztürk
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Abstract

Objective: Overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) is thought to be more aggressive in gastric cancer. This study aimed to evaluate the predictability of HER2 status and other prognostic pathologic parameters using [18F]FDG PET/CT and to investigate its impact on survival.

Methods: Pretreatment metabolic parameters measured by [18F]FDG PET/CT as a prognostic factor were retrospectively evaluated in 117 HER2-analysed patients. The relationship between pathological data, tumor metabolic characteristics, and distant metastases was examined, and the effect on survival was investigated.

Results: Among the 117 patients, 17.1% were HER2-positive (HER2+), and 82.9% were HER2-negative (HER2-). There was no significant association between PET/CT parameters in the HER2+ and HER2- patient groups. HER2+ patients had higher 1- and 3-year survival expectations than HER2- patients (80%-%37.9; %47.5-%20; respectively). There was no statistically significant difference in overall survival. In Cox-regression analysis, while the presence of vascular invasion, local invasion, and distant metastasis were poor prognostic factors, HER2 was not a prognostic factor. Vascular invasion and local invasion (T3/T4) were also associated with higher SUVmax values. Patients with distant metastases had significantly higher SUVmax, SUVmean, and TLG.

Conclusion: This study showed no association between HER2 expression and [18F]FDG PET/CT metabolic parameters. However, regardless of HER2 status, the results indicated distant metastasis, local invasion, and vascular invasion could be associated with primary tumor metabolism. PET/CT parameters predict tumor aggressiveness and disease prognosis better than HER2 status.

胃腺癌病理数据获取的HER2状态与治疗前代谢参数的关系[18F]。
目的:人表皮生长因子受体2 (HER2)过表达被认为在胃癌中更具侵袭性。本研究旨在利用[18F]FDG PET/CT评估HER2状态和其他预后病理参数的可预测性,并探讨其对生存的影响。方法:回顾性评价117例her2分析患者的预处理代谢参数[18F]FDG PET/CT作为预后因素。检查病理资料、肿瘤代谢特征与远处转移的关系,并探讨对生存的影响。结果:117例患者中HER2阳性(HER2+)占17.1%,HER2阴性(HER2-)占82.9%。HER2+和HER2-患者组PET/CT参数之间无显著相关性。HER2+患者的1年和3年生存预期高于HER2-患者(80%-%37.9;% 47.5 - % 20;分别)。两组总生存率无统计学差异。cox -回归分析中,血管浸润、局部浸润和远处转移是不良预后因素,HER2不是预后因素。血管侵犯和局部侵犯(T3/T4)也与较高的SUVmax值相关。远处转移患者的SUVmax、SUVmean和TLG显著升高。结论:本研究显示HER2表达与[18F]FDG PET/CT代谢参数无相关性。然而,无论HER2状态如何,结果表明远处转移、局部侵袭和血管侵袭可能与原发性肿瘤代谢有关。PET/CT参数预测肿瘤侵袭性和疾病预后优于HER2状态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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