A step towards non-invasive diagnosis of diabetes mellitus using in situ synthesized MOF–MXene hybrid material with extended gate field-effect transistor integration†
Mallikarjuna Swamy Shabanur Matada, Rahul Suresh Ghuge, Surya Velappa Jayaraman, Corrado Di Natale and Yuvaraj Sivalingam
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引用次数: 0
Abstract
The increasing demand for non-invasive and non-enzymatic glucose sensors is driven by the objective of eliminating the need for blood pricks from the body and enabling enzyme-free detection of glucose for diagnosing diabetes mellitus. To address this need, we synthesized Ni MOF–MXene (NiBDC-MXene) hybrid material through a one-pot synthesis method, which acts as a catalyst to detect salivary glucose using an extended gate field effect transistor (EGFET) method. The resulting sensor exhibits good selectivity towards glucose over common interfering molecules such as sucrose, fructose, maltose, uric acid, and ascorbic acid under physiological conditions in saliva. The fabricated electrode demonstrated high sensitivity of 531.78 μA mM−1 cm−2 with a detection range of 10 μM to 1100 μM, a sensor response time of less than 5 s, and a limit of detection (LOD) of 0.29 μM. The real saliva sample measurements under postabsorptive and postprandial conditions highlight the electrode's effectiveness in detecting salivary glucose. In addition to EGFET measurements, scanning Kelvin probe (SKP) measurements were performed to understand the mechanism of charge transfer between the glucose and NiBDC-MXene/CP electrode. Overall, the EGFET results demonstrate the capability of the sensor to detect salivary glucose in hypoglycemia, normal, and hyperglycemia ranges.
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices