A step towards non-invasive diagnosis of diabetes mellitus using in situ synthesized MOF–MXene hybrid material with extended gate field-effect transistor integration†

IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Mallikarjuna Swamy Shabanur Matada, Rahul Suresh Ghuge, Surya Velappa Jayaraman, Corrado Di Natale and Yuvaraj Sivalingam
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Abstract

The increasing demand for non-invasive and non-enzymatic glucose sensors is driven by the objective of eliminating the need for blood pricks from the body and enabling enzyme-free detection of glucose for diagnosing diabetes mellitus. To address this need, we synthesized Ni MOF–MXene (NiBDC-MXene) hybrid material through a one-pot synthesis method, which acts as a catalyst to detect salivary glucose using an extended gate field effect transistor (EGFET) method. The resulting sensor exhibits good selectivity towards glucose over common interfering molecules such as sucrose, fructose, maltose, uric acid, and ascorbic acid under physiological conditions in saliva. The fabricated electrode demonstrated high sensitivity of 531.78 μA mM−1 cm−2 with a detection range of 10 μM to 1100 μM, a sensor response time of less than 5 s, and a limit of detection (LOD) of 0.29 μM. The real saliva sample measurements under postabsorptive and postprandial conditions highlight the electrode's effectiveness in detecting salivary glucose. In addition to EGFET measurements, scanning Kelvin probe (SKP) measurements were performed to understand the mechanism of charge transfer between the glucose and NiBDC-MXene/CP electrode. Overall, the EGFET results demonstrate the capability of the sensor to detect salivary glucose in hypoglycemia, normal, and hyperglycemia ranges.

Abstract Image

扩展栅场效应晶体管集成原位合成MOF-MXene杂化材料在糖尿病无创诊断中的应用。
对非侵入性和非酶促血糖传感器的需求日益增长,其目的是消除对血液穿刺的需要,并使诊断糖尿病的无酶血糖检测成为可能。为了解决这一需求,我们通过一锅合成方法合成了Ni MOF-MXene (NiBDC-MXene)杂化材料,并利用扩展栅极场效应晶体管(EGFET)方法作为催化剂检测唾液葡萄糖。在唾液的生理条件下,该传感器对葡萄糖表现出良好的选择性,优于蔗糖、果糖、麦芽糖、尿酸和抗坏血酸等常见干扰分子。该电极的灵敏度为531.78 μA mM-1 cm-2,检测范围为10 μM ~ 1100 μM,传感器响应时间小于5 s,检测限(LOD)为0.29 μM。在吸收后和餐后条件下的真实唾液样本测量突出了电极在检测唾液葡萄糖方面的有效性。除了EGFET测量外,还进行了扫描开尔文探针(SKP)测量,以了解葡萄糖和NiBDC-MXene/CP电极之间的电荷转移机制。总的来说,EGFET结果证明了传感器在低血糖、正常和高血糖范围内检测唾液葡萄糖的能力。
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来源期刊
Journal of Materials Chemistry B
Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.30%
发文量
866
期刊介绍: Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive: Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices
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