A virtual reality cognitive screening tool based on the six cognitive domains.

IF 4 Q1 CLINICAL NEUROLOGY

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2024-12-20 eCollection Date: 2024-10-01 DOI:10.1002/dad2.70030

Ngiap Chuan Tan, Jie En Lim, Rehena Sultana, Joanne Hui Min Quah, Wei Teen Wong

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引用次数: 0

Abstract

Introduction: Early detection of cognitive impairment enables interventions to slow cognitive decline. Existing neuropsychological paper-and-pencil tests may not adequately assess cognition in real-life environments. A fully-immersive and automated virtual reality (VR) system-Cognitive Assessment using VIrtual REality (CAVIRE)-was developed to assess all six cognitive domains. This case-control study aims to evaluate the ability of CAVIRE to differentiate cognitively-healthy individuals from those with cognitive impairment.

Methods: One hundred nine Asian individuals 65-84 years of age were recruited at a primary care setting in Singapore. Based on the Montreal Cognitive Assessment (MoCA), participants were grouped as either Cognitively Healthy (MoCA ≥26, n = 60) or Cognitively Impaired (MoCA <26, n = 49). Subsequently, all participants completed the CAVIRE assessment.

Results: Cognitively-healthy participants achieved higher VR scores and required shorter completion time across all six cognitive domains (all p's < 0.005). Receiver-operating characteristic curve analysis showed area under the curve of 0.7267.

Discussion: The results demonstrated the potential of CAVIRE as a cognitive screening tool in primary care.

Highlights: CAVIRE is a virtual reality (VR) system that assesses the six cognitive domains.CAVIRE can distinguish healthy individuals from individuals with cognitive impairment.It has potential as a cognitive screening tool for older people in primary care.

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基于六个认知域的虚拟现实认知筛选工具。

早期发现认知障碍可以通过干预来减缓认知能力下降。现有的神经心理学纸笔测试可能无法充分评估现实环境中的认知能力。开发了一个完全沉浸式和自动化的虚拟现实（VR）系统-使用虚拟现实的认知评估(CAVIRE)-来评估所有六个认知领域。本病例对照研究旨在评估CAVIRE区分认知健康个体与认知障碍个体的能力。方法：在新加坡的一家初级保健机构招募了109名65-84岁的亚洲人。根据蒙特利尔认知评估（MoCA），参与者分为认知健康组（MoCA≥26,n = 60）和认知受损组（MoCA n = 49）。随后，所有参与者完成CAVIRE评估。结果：认知健康的参与者在所有六个认知领域获得了更高的VR分数，并且需要更短的完成时间(讨论：结果证明了CAVIRE作为初级保健认知筛查工具的潜力。CAVIRE是一个虚拟现实（VR）系统，评估六个认知领域。CAVIRE可以区分健康个体和认知障碍个体。它有潜力作为初级保健老年人的认知筛查工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Medicine-Psychiatry and Mental Health

CiteScore

7.80

自引率

7.50%

发文量

101

审稿时长

8 weeks

期刊介绍： Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.