Gut microbiome and obesity in late adolescence: A case-control study in “Children of 1997” birth cohort

IF 3.3 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Baoting He PhD , Sheng Xu PhD , C. Mary Schooling PhD , Gabriel M. Leung MD , Joshua W.K. Ho PhD , Shiu Lun Au Yeung PhD
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Abstract

Purpose

Although the gut microbiome is important in human health, its relation to adolescent obesity remains unclear. Here we assessed the associations of the gut microbiome with adolescent obesity in a case-control study.

Methods

In the “Children of 1997” birth cohort, participants with and without obesity at ∼17.4 years were 1:1 matched on sex, physical activity, parental education and occupation (n = 312). Fecal gut microbiome composition and pathways were assessed via shotgun metagenomic sequencing. The association of microbiota species with obesity was evaluated using conditional logistic regression. We explored the association of the obesity-relevant species with adolescent metabolomics using multivariable linear regression, and causal relationships with type 2 diabetes using Mendelian randomization analysis.

Results

Gut microbiota in the adolescents with obesity exhibited lower richness (p = 0.031) and evenness (p = 0.014) compared to controls. Beta diversity revealed differences in the microbiome composition in two groups (p = 0.034). Lower relative abundance of Clostridium spiroforme, Clostridium phoceensis and Bacteroides uniformis were associated with higher obesity risk (q<0.15). Lower Bacteroides uniformis was associated with higher branched-chain amino acid, potentially contributing to higher type 2 diabetes risk.

Conclusion

Adolescents with obesity had a distinct gut microbiota profile compared to the controls, possibly linked to metabolic pertubation and related diseases.
青春期后期肠道微生物群与肥胖:1997年出生队列儿童的病例对照研究
目的:虽然肠道微生物组对人类健康很重要,但其与青少年肥胖的关系尚不清楚。在这里,我们在一项病例对照研究中评估了肠道微生物组与青少年肥胖的关系。方法:在“1997年儿童”出生队列中,年龄为17.4岁的肥胖者和非肥胖者按性别、体育活动、父母受教育程度和职业按1:1匹配(n=312)。通过霰弹枪宏基因组测序评估粪便肠道微生物组组成和途径。使用条件逻辑回归评估微生物群种类与肥胖的关系。我们利用多变量线性回归探讨了肥胖相关物种与青少年代谢组学的关系,并利用孟德尔随机化分析探讨了肥胖相关物种与2型糖尿病的因果关系。结果:与对照组相比,肥胖青少年肠道菌群的丰富度(p=0.031)和均匀度(p=0.014)较低。β多样性揭示了两组微生物组组成的差异(p=0.034)。螺旋状梭状芽胞杆菌、phoceensis梭状芽胞杆菌和拟杆菌的相对丰度较低与较高的肥胖风险相关(结论:与对照组相比,肥胖青少年的肠道微生物群特征明显,可能与代谢紊乱和相关疾病有关。
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来源期刊
Annals of Epidemiology
Annals of Epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
7.40
自引率
1.80%
发文量
207
审稿时长
59 days
期刊介绍: The journal emphasizes the application of epidemiologic methods to issues that affect the distribution and determinants of human illness in diverse contexts. Its primary focus is on chronic and acute conditions of diverse etiologies and of major importance to clinical medicine, public health, and health care delivery.
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