Interferon Point Alteration in Hospitalized Patients with and Without COVID-19.

IF 0.8 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

Medical Acupuncture Pub Date : 2024-12-17 eCollection Date: 2024-12-01 DOI:10.1089/acu.2023.0095

Mehran Rezvani Habibabadi, Mahmoud Saghaei, Ali Ghahramani, Mohammadreza Habibzadeh Siahroadkolaee, Shirin Fattahpour, Sayed Mostafa Hashemi

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引用次数: 0

Abstract

Introduction: Integrating traditional Chinese medicine with Western medicine has been extensively studied in managing respiratory disease. Therefore, in this study, we aimed to examine interferon point alteration (IPA) and its association with disease severity in patients with COVID-19.

Methods: This cross-sectional study was conducted on patients hospitalized due to COVID-19 with lung involvement. The control group consisted of patients hospitalized with a diagnosis other than COVID-19. The prevalence of IPA was compared between patients with and without COVID-19. Clinical and laboratory findings were compared in patients with and without IPA.

Results: A total of 126 participants, with a mean (SD) age of 57.2 (16.4) years, were included in this study. 54.8% of participants were men. There was a significant difference between patients with and without COVID-19 regarding the frequency of IPA (p = 0.045). No significant differences were observed between variables in patients with and without IPA (p ≥ 0.05). The only variable that could significantly predict the IPA in COVID-19 patients was the severity score of lung involvement in HRCT (OR: 5.32, 95% CI: 1.08-26.05, p = 0.039). IPA showed a sensitivity and specificity of 80.9% and 34.9% in identifying COVID-19 patients, respectively.

Conclusion: Our study found a significant association between IPAs and the severity of lung involvement in hospitalized COVID-19 patients and a significant association of COVID-19 with IPAs.

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COVID-19住院患者与非住院患者干扰素点的改变

中西医结合治疗呼吸系统疾病已被广泛研究。因此，在本研究中，我们旨在研究干扰素点改变（IPA）及其与COVID-19患者疾病严重程度的关系。方法：对新冠肺炎累及肺部住院患者进行横断面研究。对照组由非COVID-19诊断住院的患者组成。比较合并和未合并COVID-19患者IPA的患病率。比较了有和没有IPA患者的临床和实验室结果。结果：本次研究共纳入126名参与者，平均（SD）年龄为57.2（16.4）岁。54.8%的参与者为男性。合并和未合并COVID-19的患者IPA发生频率差异有统计学意义（p = 0.045）。IPA患者与非IPA患者各指标间无显著差异（p≥0.05）。唯一能显著预测COVID-19患者IPA的变量是HRCT肺部受累严重程度评分（OR: 5.32, 95% CI: 1.08-26.05, p = 0.039）。IPA对COVID-19患者的敏感性为80.9%，特异性为34.9%。结论：我们的研究发现IPAs与住院COVID-19患者肺部受累严重程度之间存在显著相关性，并且COVID-19与IPAs之间存在显著相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Acupuncture INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

1.80

自引率

18.20%

发文量