The value of promoter methylation of fibroblast factor 21 (FGF21) in predicting the course of chronic hepatitis B and the occurrence of oxidative stress.

IF 4 3区医学 Q2 VIROLOGY

Virology Journal Pub Date : 2024-12-23 DOI:10.1186/s12985-024-02605-6

Xue Li, Pei Liu, Zhaohui Wang, Xuefei Wei, Shuai Gao, YuChen Fan, Huihui Liu, Kai Wang

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引用次数: 0

Abstract

Background: Oxidative stress plays a crucial role in the pathogenesis of HBV. This study aimed to investigate the value of fibroblast growth factor 21 (FGF21) promoter methylation in the occurrence and development of chronic hepatitis B (CHB) oxidative stress.

Methods: A total of 241 participants including 221 patients with CHB and 20 healthy controls (HCs) were recruited. Methylation level of FGF21 promoter in peripheral blood mononuclear cells was quantitatively determined. Enzyme-linked immunosorbent assay was used to assess oxidative stress in CHB patients.

Results: Our study shows that the FGF21 methylation level was significantly lower in HBeAg-positive CHB patients compared to HBeAg-negative CHB patients and HCs (P < 0.0001). The oxidative stress of HBeAg-positive CHB patients was more severe. Further correlation analysis showed that there was a significant correlation between the methylation level of FGF21 promoter and the occurrence of oxidative stress in CHB patients. In addition, assessment based on FGF21 promoter methylation level proved effective for predicting oxidative stress occurrence and disease progression among CHB patients.

Conclusion: FGF21 promoter methylation level is an important marker for predicting oxidative stress and disease progression in patients with CHB.

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成纤维细胞因子21 （FGF21）启动子甲基化在预测慢性乙型肝炎病程和氧化应激发生中的价值。

背景：氧化应激在HBV的发病机制中起重要作用。本研究旨在探讨成纤维细胞生长因子21 （FGF21）启动子甲基化在慢性乙型肝炎（CHB）氧化应激发生发展中的价值。方法：共招募了241名参与者，其中包括221名CHB患者和20名健康对照（hc）。定量测定外周血单个核细胞中FGF21启动子甲基化水平。采用酶联免疫吸附法评估慢性乙型肝炎患者的氧化应激。结果：我们的研究表明，与hbeag阴性CHB患者和hc相比，hbeag阳性CHB患者的FGF21甲基化水平显著降低(P结论：FGF21启动子甲基化水平是预测CHB患者氧化应激和疾病进展的重要指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Virology Journal 医学-病毒学

CiteScore

7.40

自引率

2.10%

发文量

186

审稿时长

1 months

期刊介绍： Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.