Effects of enriched environment on barrel cortex and hippocampus function following somatosensory damage in rat

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Physiology & Behavior Pub Date : 2024-12-20 DOI:10.1016/j.physbeh.2024.114785

Melika Farhadi , Mohammad Reza Afarinesh , Vahid Sheibani , Mansoureh Sabzalizadeh

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引用次数: 0

Abstract

Objectives

This study investigated the effects of environmental enrichment (EE) on the behavior and histological alterations of rats with barrel cortex damage.

Methods

Forty-eight adult male rats were divided into Control (Ctrl), Lesion, Lesion+EE.S (Lesion+Standard Enriched Environment, and Lesion+EE.T (Lesion+Tactile Enriched Environment) groups. The animals were first anesthetized, and then, a cold lesion model was performed on the parietal cortex. After surgery, the rats were exposed to a standard enriched environment or enriched environment with tactile for 30 days. Their cognitive behaviors were assessed using an open field, novel texture discrimination, and Morris water maze (MWM) tests. In addition, a histological investigation was conducted to determine the degree of degeneration of hippocampal and somatosensory cortex neurons.

Results

The results demonstrated that rats with barrel cortex lesions revealed impairments in novel texture discrimination and MWM tests (P<0.001). Moreover, lesions increased neuronal degeneration in rats’ barrel cortex and hippocampus (P< 0.001). Environmental enrichment improved behavioral deficits and decreased neuronal degeneration in the barrel cortex and hippocampus of rats with barrel cortex lesions (P<0.05).

Conclusion

The current study suggests that barrel cortex lesions create cognitive and behavioral deficits and neural degeneration in the barrel cortex and hippocampus; however, environmental enrichment could reverse these impairments.

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强化环境对大鼠体感觉损伤后桶状皮质和海马功能的影响。

目的：研究环境富集（EE）对桶状皮质损伤大鼠行为和组织学改变的影响。方法：48只成年雄性大鼠分为对照组、病变组、病变+EE组。S（病变+标准富集环境，病变+EE）。T（病变+触觉富集环境）组。先对动物进行麻醉，然后在顶叶皮层建立冷损伤模型。术后将大鼠置于标准强化环境或有触觉的强化环境30天。采用开放场、新型纹理辨别和Morris水迷宫（MWM）测试评估受试者的认知行为。此外，我们还进行了组织学检查，以确定海马和体感觉皮层神经元的退化程度。结果：结果表明，桶状皮质损伤大鼠在新纹理识别和MWM测试中表现出损伤(p)。结论：桶状皮质损伤导致桶状皮质和海马的认知和行为缺陷以及神经变性；然而，环境富集可以逆转这些损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physiology & Behavior 医学-行为科学

CiteScore

5.70

自引率

3.40%

发文量

274

审稿时长

47 days

期刊介绍： Physiology & Behavior is aimed at the causal physiological mechanisms of behavior and its modulation by environmental factors. The journal invites original reports in the broad area of behavioral and cognitive neuroscience, in which at least one variable is physiological and the primary emphasis and theoretical context are behavioral. The range of subjects includes behavioral neuroendocrinology, psychoneuroimmunology, learning and memory, ingestion, social behavior, and studies related to the mechanisms of psychopathology. Contemporary reviews and theoretical articles are welcomed and the Editors invite such proposals from interested authors.