[Less iron deficiency in whole-blood donors: the effect of ferritin-guided donation intervals].

Q4 Medicine

Nederlands tijdschrift voor geneeskunde Pub Date : 2024-12-31

Amber Meulenbeld, Steven Ramondt, Maaike G Sweegers, Franke A Quee, Femmeke J Prinsze, Emiel O Hoogendijk, Dorine W Swinkels, Katja van den Hurk

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引用次数: 0

Abstract

Objective: To evaluate the effect of ferritin-guided donation intervals on haemoglobin (Hb) and ferritin levels, iron deficiency and low Hb deferrals in whole-blood donors.

Design: A cluster-randomized stepped-wedge trial.

Methods: In 2017-2019, Sanquin gradually implemented ferritin-guided donation intervals. Ferritin levels are measured in new donors and at every fifth donation. Donors with ferritin levels ≤ 30 ng/mL are deferred for 6-12 months. Additionally, we assessed donor return within six months.

Results: In the 36 months following the implementation of the policy, the percentage of donors with iron deficiency, low ferritin, and low Hb decreased. Additionally, Hb and ferritin levels increased significantly compared to the previous policy. In males, odds of return decreased significantly after implementation of the new policy.

Conclusion: Ferritin-guided donation intervals effectively improve donors' iron status, but necessitate additional efforts in donor recruitment and retention.

本刊更多论文

[全血献血者较少缺铁：铁蛋白引导的献血间隔的影响]。

目的：评价铁蛋白引导的献血间隔对全血献血者血红蛋白（Hb）和铁蛋白水平、铁缺乏和低Hb延迟的影响。设计：整群随机楔形试验。方法：2017-2019年，Sanquin逐步实施铁蛋白引导捐赠间隔。在新献血者和每五次献血者中测量铁蛋白水平。铁蛋白水平≤30 ng/mL的供体推迟6-12个月。此外，我们评估了6个月内捐赠者的回报。结果：政策实施后36个月内，供体缺铁、低铁蛋白、低血红蛋白的比例下降。此外，血红蛋白和铁蛋白水平明显高于之前的政策。在男性中，新政策实施后，回报率显著下降。结论：铁蛋白引导下的捐献间隔有效改善了献血者的铁状态，但需要在献血者的招募和保留方面付出额外的努力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nederlands tijdschrift voor geneeskunde Medicine-Medicine (all)

CiteScore

0.30

自引率

0.00%

发文量

302

期刊介绍： Het NTVG staat bekend als hét wetenschappelijke algemene medische tijdschrift. De lange historie en de degelijkheid maken het tijdschrift tot een bolwerk van medische wetenschap in druk. Ook door de goede leesbaarheid draagt het tijdschrift bij aan de voortdurende dialoog over de geneeskunde.