The Pace of Biological Aging Partially Explains the Relationship Between Socioeconomic Status and Chronic Low Back Pain Outcomes.

IF 2.5 3区 医学 Q2 CLINICAL NEUROLOGY
Journal of Pain Research Pub Date : 2024-12-17 eCollection Date: 2024-01-01 DOI:10.2147/JPR.S481452
Edwin N Aroke, Jai Ganesh Nagidi, Vinodh Srinivasasainagendra, Tammie L Quinn, Fiona B A T Agbor, Kiari R Kinnie, Hemant K Tiwari, Burel R Goodin
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引用次数: 0

Abstract

Introduction: Having a lower socioeconomic status (SES) is a predictor of age-related chronic conditions, including chronic low back pain (cLBP). We aimed to examine whether the pace of biological aging mediates the relationship between SES and cLBP outcomes - pain intensity, pain interference, and physical performance.

Methods: We used the Dunedin Pace of Aging Calculated from the Epigenome (DunedinPACE) software to determine the pace of biological aging in adults ages 18 to 85 years with no cLBP (n = 74), low-impact pain (n = 56), and high-impact pain (n = 77).

Results: The mean chronological age of the participants was 40.9 years (SD= 15.1); 107 (51.7%) were female, and 108 (52.2%) were Black. On average, the pace of biological aging was 5% faster [DunedinPACE = 1.05 (SD = 0.14)] in the sample (DunedinPACE value of 1 = normal pace of aging). Individuals with higher levels of education had a significantly slower pace of biological aging than those with lower education levels (F = 5.546, p = 0.001). After adjusting for sex and race, household income level significantly correlated with the pace of biological aging (r = -0.17, p = 0.02), pain intensity (r = -0.21, p = 0.003), pain interference (r = -0.21, p = 0.003), and physical performance (r = 0.20, p = 0.005). In mediation analyses adjusting for sex, race, and body mass index (BMI), the pace of biological aging mediates the relationship between household income (but not education) level and cLBP intensity, interference, as well as physical performance.

Discussion: Results indicate that lower SES contributes to faster biological aging, possibly contributing to greater pain intensity and interference, as well as lower physical performance. Future interventions slowing the pace of biological aging may improve cLBP outcomes.

生物衰老的速度部分解释了社会经济地位与慢性腰痛结局之间的关系。
引言:较低的社会经济地位(SES)是年龄相关慢性疾病的预测因子,包括慢性腰痛(cLBP)。我们的目的是研究生物衰老的速度是否介导了SES和cLBP结果(疼痛强度、疼痛干扰和身体表现)之间的关系。方法:我们使用从表观基因组(DunedinPACE)软件计算的Dunedin衰老速度来确定18至85岁无cLBP (n = 74),低冲击疼痛(n = 56)和高冲击疼痛(n = 77)的成年人的生物衰老速度。结果:参与者的平均实足年龄为40.9岁(SD= 15.1);女性107例(51.7%),黑人108例(52.2%)。样本生物衰老速度平均快5% [DunedinPACE = 1.05 (SD = 0.14)] (DunedinPACE值为1 =正常衰老速度)。受教育程度高的个体生物衰老速度明显慢于受教育程度低的个体(F = 5.546, p = 0.001)。在调整性别和种族后,家庭收入水平与生物衰老速度(r = -0.17, p = 0.02)、疼痛强度(r = -0.21, p = 0.003)、疼痛干扰(r = -0.21, p = 0.003)和体能表现(r = 0.20, p = 0.005)显著相关。在调整性别、种族和身体质量指数(BMI)的中介分析中,生物衰老的速度调节了家庭收入(而不是教育)水平与cLBP强度、干扰以及身体表现之间的关系。讨论:结果表明,较低的SES有助于更快的生物老化,可能会导致更大的疼痛强度和干扰,以及更低的身体表现。未来干预减缓生物衰老的步伐可能会改善cLBP的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Pain Research
Journal of Pain Research CLINICAL NEUROLOGY-
CiteScore
4.50
自引率
3.70%
发文量
411
审稿时长
16 weeks
期刊介绍: Journal of Pain Research is an international, peer-reviewed, open access journal that welcomes laboratory and clinical findings in the fields of pain research and the prevention and management of pain. Original research, reviews, symposium reports, hypothesis formation and commentaries are all considered for publication. Additionally, the journal now welcomes the submission of pain-policy-related editorials and commentaries, particularly in regard to ethical, regulatory, forensic, and other legal issues in pain medicine, and to the education of pain practitioners and researchers.
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