{"title":"Polyketide production in a mangrove-associated fungus <i>Diaporthe goulteri</i>, induced by chemical epigenetic modification.","authors":"Xiaolin Ma, Xia Wei, Shangping Xing, Xue Cheng, Junfei Lu, Chunxia Yang, Genshi Zhao, Ziteng Dai, Shiyu Hou, Yanying Liu, Dan Zhu","doi":"10.1080/14786419.2024.2441496","DOIUrl":null,"url":null,"abstract":"<p><p>Studies on the chemical composition of endophytic fungus <i>Diaporthe goulteri</i>, isolated from the <i>Acanthus ilicifolius</i> L., by using epigenetic modification to activate clusters of biosynthetic genes that are silenced or poorly expressed in fungi, resulting in obtainment of ten polyketides. Among these compounds were six new compounds, including cytosporin E2 (<b>1</b>), cytosporin D1 (<b>2</b>), cytosporin G1 (<b>3</b>), cytosporin J1 (<b>4</b>), cytosporin K1 (<b>5</b>), cytosporin F1 (<b>6</b>), and four known compounds, cytosporin E (<b>7</b>), cytosporin Y3 (<b>8</b>), cytosporin D (<b>9</b>), and cytosporin L (<b>10</b>). The structures of the compounds were established by comprehensive spectroscopic analysis, quantum-chemical calculations, and the modified Mosher's method. The cytotoxic, antioxidant and anti-inflammatory activities of the isolated compounds were evaluated.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.9000,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2441496","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
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Abstract
Studies on the chemical composition of endophytic fungus Diaporthe goulteri, isolated from the Acanthus ilicifolius L., by using epigenetic modification to activate clusters of biosynthetic genes that are silenced or poorly expressed in fungi, resulting in obtainment of ten polyketides. Among these compounds were six new compounds, including cytosporin E2 (1), cytosporin D1 (2), cytosporin G1 (3), cytosporin J1 (4), cytosporin K1 (5), cytosporin F1 (6), and four known compounds, cytosporin E (7), cytosporin Y3 (8), cytosporin D (9), and cytosporin L (10). The structures of the compounds were established by comprehensive spectroscopic analysis, quantum-chemical calculations, and the modified Mosher's method. The cytotoxic, antioxidant and anti-inflammatory activities of the isolated compounds were evaluated.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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